Hideki Ueno1, Yojiro Hashiguchi2, Hideyuki Shimazaki3, Eiji Shinto4, Yoshiki Kajiwara4, Kuniaki Nakanishi3, Kei Kato3, Kazuya Maekawa3, Takahiro Nakamura5, Junji Yamamoto4, Kazuo Hase4. 1. Department of Surgery, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan. Electronic address: ueno@ndmc.ac.jp. 2. Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan. 3. Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan. 4. Department of Surgery, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan. 5. Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan; Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
Abstract
BACKGROUND: The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC). METHODS: A total of 695 patients with pT3/T4 CRC (1980 to 1999) were reviewed. Tumor deposits located ≥2 mm from the front of the direct spread in the primary tumor were evaluated as PTDs. RESULTS: PTDs were observed in 111 patients (16.0%). The incidence of PTDs increased according to increasing N stage: 7% for N0, 22% for N1, and 39% for N2 (P < .0001). Five-year disease-specific survival was 85.0% in patients without PTDs and 59.5% in those with PTDs (P < .0001). Multivariate analysis showed that PTDs affected disease-specific survival independent of T and N stages. A significant prognostic impact of PTDs was similarly observed in another cohort comprising 474 patients with pT3/T4 CRC (2000 to 2005). The κ values among 8 observers were .70 for PTDs and .32 for the conventional growth pattern. CONCLUSIONS: PTDs have considerable prognostic relevance and offer improved judgment reproducibility in assessing the invasive margin of CRC.
BACKGROUND: The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC). METHODS: A total of 695 patients with pT3/T4 CRC (1980 to 1999) were reviewed. Tumor deposits located ≥2 mm from the front of the direct spread in the primary tumor were evaluated as PTDs. RESULTS: PTDs were observed in 111 patients (16.0%). The incidence of PTDs increased according to increasing N stage: 7% for N0, 22% for N1, and 39% for N2 (P < .0001). Five-year disease-specific survival was 85.0% in patients without PTDs and 59.5% in those with PTDs (P < .0001). Multivariate analysis showed that PTDs affected disease-specific survival independent of T and N stages. A significant prognostic impact of PTDs was similarly observed in another cohort comprising 474 patients with pT3/T4 CRC (2000 to 2005). The κ values among 8 observers were .70 for PTDs and .32 for the conventional growth pattern. CONCLUSIONS: PTDs have considerable prognostic relevance and offer improved judgment reproducibility in assessing the invasive margin of CRC.
Authors: Ming Jin; Rachel Roth; Jonathan B Rock; Mary Kay Washington; Amy Lehman; Wendy L Frankel Journal: Am J Surg Pathol Date: 2015-01 Impact factor: 6.394