Literature DB >> 24112325

Ibogaine related sudden death: a case report.

Stavroula A Papadodima1, Artemis Dona, Christos I Evaggelakos, Nikolaos Goutas, Sotirios A Athanaselis.   

Abstract

Ibogaine is a naturally occurring alkaloid derived from the roots of the rain forest shrub Tabernanthe iboga. Deaths have occurred temporarily related to the use of ibogaine. However, although not licensed as therapeutic drug, and despite evidence that ibogaine may disturb the rhythm of the heart, this alkaloid is currently used as an anti-addiction drug in alternative medicine for detoxification purposes. We report the case of a man who died suddenly 12-24 h after ibogaine use for alcohol detoxification treatment. In the autopsy liver cirrhosis and heavy fatty infiltration was found. The concentration of ibogaine was 2 mg/l. The potential risks of ibogaine use, especially for persons with pathological medical background, are discussed.
Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Entities:  

Keywords:  Autopsy; Cardiac death; Death; Fatty infiltration of the liver; Ibogaine

Mesh:

Substances:

Year:  2013        PMID: 24112325     DOI: 10.1016/j.jflm.2013.06.032

Source DB:  PubMed          Journal:  J Forensic Leg Med        ISSN: 1752-928X            Impact factor:   1.614


  4 in total

Review 1.  Clinical applications of hallucinogens: A review.

Authors:  Albert Garcia-Romeu; Brennan Kersgaard; Peter H Addy
Journal:  Exp Clin Psychopharmacol       Date:  2016-08       Impact factor: 3.157

Review 2.  The anti-addiction drug ibogaine and the heart: a delicate relation.

Authors:  Xaver Koenig; Karlheinz Hilber
Journal:  Molecules       Date:  2015-01-29       Impact factor: 4.411

Review 3.  Herbal Highs: Review on Psychoactive Effects and Neuropharmacology.

Authors:  Silvia Graziano; Laura Orsolini; Maria Concetta Rotolo; Roberta Tittarelli; Fabrizio Schifano; Simona Pichini
Journal:  Curr Neuropharmacol       Date:  2017       Impact factor: 7.363

4.  Anti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Authors:  Lena Rubi; Daniel Eckert; Stefan Boehm; Karlheinz Hilber; Xaver Koenig
Journal:  Cardiovasc Toxicol       Date:  2017-04       Impact factor: 3.231

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.