Literature DB >> 2411218

Elimination of multicopy plasmid R6K by bleomycin.

P V Attfield, R J Pinney.   

Abstract

Bleomycin eliminated multicopy plasmid R6K from growing cells of Escherichia coli AB1157 but failed to cure either of the low-copy plasmids R1 or R46. Measurements of R6K-encoded beta-lactamase and of covalently closed plasmid DNA indicated that the drug causes a progressive reduction in plasmid copy number.

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Year:  1985        PMID： 2411218      PMCID： PMC180205          DOI： 10.1128/AAC.27.6.985

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Pedigrees of some mutant strains of Escherichia coli K-12.

Authors:  B J Bachmann
Journal:  Bacteriol Rev       Date:  1972-12

2.  Competition for DNA polymerase III between the chromosome and the R-factor R1.

Authors:  U M Nordström; B Engberg; K Nordström
Journal:  Mol Gen Genet       Date:  1974

3.  R factor elimination by inhibitors of thymidylate synthetase (fluorodeoxyuridine and showdomycin) and the occurrence of single strand breaks in plasmid DNA.

Authors:  R J Pinney; K Bremer; J T Smith
Journal:  Mol Gen Genet       Date:  1974

4.  Origin of the TEM-beta-lactamase gene found on plasmids.

Authors:  F Heffron; R Sublett; R W Hedges; A Jacob; S Falkow
Journal:  J Bacteriol       Date:  1975-04       Impact factor: 3.490

5.  Elimination of resistance determinants from R-factor R1 by intercalative compounds.

Authors:  F E Hahn; J Ciak
Journal:  Antimicrob Agents Chemother       Date:  1976-01       Impact factor: 5.191

6.  Characterization of long patch excision repair of DNA in ultraviolet-irradiated Escherichia coli: an inducible function under rec-lex control.

Authors:  P K Cooper
Journal:  Mol Gen Genet       Date:  1982

7.  On the mechanism of action of bleomycin: scission of DNA strands in vitro and in vivo.

Authors:  H Suzuki; K Nagai; H Yamaki; N Tanaka; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1969-09       Impact factor: 2.649

8.  Mode of replication of the conjugative R-plasmid RSF1040 in Escherichia coli.

Authors:  J H Crosa; L K Luttropp; S Falkow
Journal:  J Bacteriol       Date:  1976-04       Impact factor: 3.490

9.  The purification and properties of the -lactamase specified by the resistance factor R-1818 in Escherichia coli and Proteus mirabilis.

Authors:  J W Dale; J T Smith
Journal:  Biochem J       Date:  1971-07       Impact factor: 3.857

10.  R6K plasmid replication: influence of chromosomal genotype in minicell-producing strains of Escherichia coli K-12.

Authors:  F L Macrina; G G Weatherly; R Curtiss
Journal:  J Bacteriol       Date:  1974-12       Impact factor: 3.490
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