A neural mass model of spontaneous burst suppression and epileptic seizures.

The paper presents a neural mass model that is capable of simulating the transition to and from various forms of paroxysmal activity such as burst suppression and epileptic seizure-like waveforms. These events occur without changing parameters in the model. The model is based on existing neural mass models, with the addition of feedback of fast dynamics to create slowly time varying parameters, or slow states. The goal of this research is to establish a link between system properties that modulate neural activity and the fast changing dynamics, such as membrane potentials and firing rates that can be manipulated using electrical stimulation. Establishing this link is likely to be a necessary component of a closed-loop system for feedback control of pathological neural activity.