| Literature DB >> 24110741 |
Chinyere I Nwabugwu, Kavya Rakhra, Dean W Felsher, David S Paik.
Abstract
Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.Entities:
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Year: 2013 PMID： 24110741 PMCID： PMC4487533 DOI： 10.1109/EMBC.2013.6610554
Source DB: PubMed Journal: Conf Proc IEEE Eng Med Biol Soc ISSN： 1557-170X