Literature DB >> 24108547

Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles.

C N P Lui1, Y P Tsui, A S L Ho, D K Y Shum, Y S Chan, C T Wu, H W Li, S C Edman Tsang, K K L Yung.   

Abstract

It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antibodies; magnetic nanoparticles; nanoparticles; regenerative medicine; stem cells

Mesh：

Substances：

Year:  2013        PMID： 24108547     DOI： 10.1002/anie.201305482

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

Review 1.  Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.

Authors:  Surya K Mallapragada; Timothy M Brenza; JoEllyn M McMillan; Balaji Narasimhan; Donald S Sakaguchi; Anup D Sharma; Svitlana Zbarska; Howard E Gendelman
Journal:  Nanomedicine       Date:  2015-01-31       Impact factor: 5.307

Review 2.  Enhancing Stem Cell-Based Therapeutic Potential by Combining Various Bioengineering Technologies.

Authors:  In-Sun Hong
Journal:  Front Cell Dev Biol       Date:  2022-07-05

3.  Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies.

Authors:  Chen-Yo Fan; Yi-Ren Hou; Avijit K Adak; Juanilita T Waniwan; Mira Anne C Dela Rosa; Penk Yeir Low; Takashi Angata; Kuo-Chu Hwang; Yu-Ju Chen; Chun-Cheng Lin
Journal:  Chem Sci       Date:  2019-08-05       Impact factor: 9.825

4.  Extracellular Nanomatrix-Induced Self-Organization of Neural Stem Cells into Miniature Substantia Nigra-Like Structures with Therapeutic Effects on Parkinsonian Rats.

Authors:  Shiqing Zhang; Peng Sun; Kaili Lin; Florence Hiu Ling Chan; Qi Gao; Wai Fung Lau; Vellaisamy A L Roy; Hongqi Zhang; King Wai Chiu Lai; Zhifeng Huang; Ken Kin Lam Yung
Journal:  Adv Sci (Weinh)       Date:  2019-09-30       Impact factor: 16.806
  4 in total

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