Literature DB >> 2410679

Modulation of calcium ion influx by the 1,4-dihydropyridines nifedipine and BAY K 8644.

M Schramm, R Towart, B Lamp, G Thomas.   

Abstract

We examined the effects of the new dihydropyridine calcium agonist BAY K 8644 on calcium influx and mechanical activity in rabbit aortic rings and compared them with those of the classical calcium antagonist nifedipine. The vasodilating effects of nifedipine and the vasoconstricting effects of BAY K 8644 can be explained by the calcium influx modulating activity of these two dihydropyridines. Only at the high concentration of 3 X 10(-6) mol/L BAY K 8644 is there a marked difference between increased calcium influx and reduced contraction.

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Year:  1985        PMID： 2410679     DOI： 10.1097/00005344-198505000-00012

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  10 in total

1.  The effects of Bay K 8644 and nifedipine on the neural responses of the rabbit ear artery.

Authors:  D W Cheung; M J MacKay
Journal:  Br J Pharmacol       Date:  1986-06       Impact factor: 8.739

2.  Characterization of dihydropyridine-sensitive calcium channels in rat brain synaptosomes.

Authors:  J J Woodward; M E Cook; S W Leslie
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

3.  Effects of the calcium channel activator Bay K 8644 on general anaesthetic potency in mice.

Authors:  S J Dolin; M J Halsey; H J Little
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

4.  Failure of the calcium channel activator, Bay K 8644, to increase the release of acetylcholine from nerve terminals in brain and diaphragm.

Authors:  V Dolezal; S Tucek
Journal:  Br J Pharmacol       Date:  1987-07       Impact factor: 8.739

5.  Effects of the calcium channel facilitator, CGP 28,392, on different modes of contraction in smooth muscle of rabbit and rat aortae and guinea-pig taenia caeci.

Authors:  H Karaki; H Nagase; H Ozaki; N Urakawa; G B Weiss
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739

6.  Correlation between the negative inotropic potency and binding parameters of 1,4-dihydropyridine and phenylalkylamine calcium channel blockers in cat heart.

Authors:  A Goll; H Glossmann; R Mannhold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-11       Impact factor: 3.000

7.  Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644.

Authors:  J M Littleton; H J Little; M A Whittington
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

8.  Calcium agonists and antagonists of the dihydropyridine type: antinociceptive effects, interference with opiate-mu-receptor agonists and neuropharmacological actions in rodents.

Authors:  F Hoffmeister; D Tettenborn
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

9.  Relationship between beta-adrenoceptors and calcium channels in human ventricular myocardium.

Authors:  D R Ferry; A J Kaumann
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

10.  Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism.

Authors:  Dong-Mei Zhang; Yong Li; Wai San Cheang; Chi Wai Lau; Shun-Ming Lin; Qian-Lan Zhang; Nan Yao; Ying Wang; Xin Wu; Yu Huang; Wen-Cai Ye
Journal:  PLoS One       Date:  2012-10-09       Impact factor: 3.240
  10 in total

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