| Literature DB >> 24106398 |
Abstract
The liver has particular tolerogenic properties that allow its spontaneous acceptance in some animal species. Liver structure is considered to favor a tolerogenic environment. The peripheral tolerance mechanisms also play a role in spontaneous tolerance to liver graft. In a clinical setting, the main challenge nowadays facing liver transplantation is minimization of immunosuppression with the goal of donor-specific tolerance. Mechanisms involved in tolerance to transplanted organs are complex and partly unknown. A significant mechanism in tolerance induction is chimerism. Chimerism can be induced through transplantation of allogeneic donor bone marrow/stem cells under appropriate host conditioning. This review focuses on the tolerance mechanisms in liver transplantation and highlights the role of chimerism and allogeneic bone marrow/stem cell transplantation in tolerance development.Entities:
Keywords: Bone marrow transplantation; Chimerism; Immunotolerance; Liver transplantation; Stem cell transplantation
Mesh：
Year: 2013 PMID： 24106398 PMCID： PMC3785619 DOI： 10.3748/wjg.v19.i36.5981
Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742