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Literature DB >> 24106297

"Inconvenient truths" in the pursuit of scientific knowledge and public health.

David A Relman¹.
1. Department of Medicine.

Abstract

Keywords: Clostridium botulinum; botulinum toxin; dual use research of concern; national security; risky science

Mesh：

Substances：
Botulinum Toxins

Year: 2013 PMID： 24106297 PMCID： PMC3873791 DOI： 10.1093/infdis/jit529

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

× No keyword cloud information.

7 in total

1. The biological century: coming to terms with risk in the life sciences.

Authors: David A Relman
Journal: Nat Immunol Date: 2010-04 Impact factor: 25.606

2. Airborne transmission of influenza A/H5N1 virus between ferrets.

Authors: Sander Herfst; Eefje J A Schrauwen; Martin Linster; Salin Chutinimitkul; Emmie de Wit; Vincent J Munster; Erin M Sorrell; Theo M Bestebroer; David F Burke; Derek J Smith; Guus F Rimmelzwaan; Albert D M E Osterhaus; Ron A M Fouchier
Journal: Science Date: 2012-06-22 Impact factor: 47.728

3. The increasingly compelling moral responsibilities of life scientists.

Authors: David A Relman
Journal: Hastings Cent Rep Date: 2013 Mar-Apr Impact factor: 2.683

Review 4. Botulinum toxin as a biological weapon: medical and public health management.

Authors: S S Arnon; R Schechter; T V Inglesby; D A Henderson; J G Bartlett; M S Ascher; E Eitzen; A D Fine; J Hauer; M Layton; S Lillibridge; M T Osterholm; T O'Toole; G Parker; T M Perl; P K Russell; D L Swerdlow; K Tonat
Journal: JAMA Date: 2001-02-28 Impact factor: 56.272

5. Molecular characterization of a novel botulinum neurotoxin type H gene.

Authors: Nir Dover; Jason R Barash; Karen K Hill; Gary Xie; Stephen S Arnon
Journal: J Infect Dis Date: 2013-10-07 Impact factor: 5.226

6. A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins.

Authors: Jason R Barash; Stephen S Arnon
Journal: J Infect Dis Date: 2013-10-07 Impact factor: 5.226

7. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets.

Authors: Masaki Imai; Tokiko Watanabe; Masato Hatta; Subash C Das; Makoto Ozawa; Kyoko Shinya; Gongxun Zhong; Anthony Hanson; Hiroaki Katsura; Shinji Watanabe; Chengjun Li; Eiryo Kawakami; Shinya Yamada; Maki Kiso; Yasuo Suzuki; Eileen A Maher; Gabriele Neumann; Yoshihiro Kawaoka
Journal: Nature Date: 2012-05-02 Impact factor: 49.962

7 in total

8 in total

"Inconvenient truths" in the pursuit of scientific knowledge and public health.

1. The biological century: coming to terms with risk in the life sciences.

2. Airborne transmission of influenza A/H5N1 virus between ferrets.

3. The increasingly compelling moral responsibilities of life scientists.

Review 4. Botulinum toxin as a biological weapon: medical and public health management.

5. Molecular characterization of a novel botulinum neurotoxin type H gene.

6. A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins.

7. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets.

1. Redaction of sensitive data in the publication of dual use research of concern.

2. Ethical alternatives to experiments with novel potential pandemic pathogens.

3. A new synthesis for dual use research of concern.

4. A New Approach to Evaluating the Risk-Benefit Equation for Dual-Use and Gain-of-Function Research of Concern.

5. Biosecurity in an age of open science.

6. Dual-use research debates and public health: better integration would do no harm.

Review 7. Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics.

Review 8. Gain-of-function experiments: time for a real debate.