Literature DB >> 24106156

Pyranonigrin E: a PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining.

Takayoshi Awakawa1, Xiao-Long Yang, Toshiyuki Wakimoto, Ikuro Abe.   

Abstract

Induced production of PKS-NRPS metabolites: the genome mining approach is useful for obtaining new compounds. We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  gene expression; genome mining; peptides; polyketides; transcriptional factors

Mesh：

Substances：

Year:  2013        PMID： 24106156     DOI： 10.1002/cbic.201300430

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  10 in total

1.  Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.

Authors:  Ronald P de Vries; Robert Riley; Ad Wiebenga; Guillermo Aguilar-Osorio; Sotiris Amillis; Cristiane Akemi Uchima; Gregor Anderluh; Mojtaba Asadollahi; Marion Askin; Kerrie Barry; Evy Battaglia; Özgür Bayram; Tiziano Benocci; Susanna A Braus-Stromeyer; Camila Caldana; David Cánovas; Gustavo C Cerqueira; Fusheng Chen; Wanping Chen; Cindy Choi; Alicia Clum; Renato Augusto Corrêa Dos Santos; André Ricardo de Lima Damásio; George Diallinas; Tamás Emri; Erzsébet Fekete; Michel Flipphi; Susanne Freyberg; Antonia Gallo; Christos Gournas; Rob Habgood; Matthieu Hainaut; María Laura Harispe; Bernard Henrissat; Kristiina S Hildén; Ryan Hope; Abeer Hossain; Eugenia Karabika; Levente Karaffa; Zsolt Karányi; Nada Kraševec; Alan Kuo; Harald Kusch; Kurt LaButti; Ellen L Lagendijk; Alla Lapidus; Anthony Levasseur; Erika Lindquist; Anna Lipzen; Antonio F Logrieco; Andrew MacCabe; Miia R Mäkelä; Iran Malavazi; Petter Melin; Vera Meyer; Natalia Mielnichuk; Márton Miskei; Ákos P Molnár; Giuseppina Mulé; Chew Yee Ngan; Margarita Orejas; Erzsébet Orosz; Jean Paul Ouedraogo; Karin M Overkamp; Hee-Soo Park; Giancarlo Perrone; Francois Piumi; Peter J Punt; Arthur F J Ram; Ana Ramón; Stefan Rauscher; Eric Record; Diego Mauricio Riaño-Pachón; Vincent Robert; Julian Röhrig; Roberto Ruller; Asaf Salamov; Nadhira S Salih; Rob A Samson; Erzsébet Sándor; Manuel Sanguinetti; Tabea Schütze; Kristina Sepčić; Ekaterina Shelest; Gavin Sherlock; Vicky Sophianopoulou; Fabio M Squina; Hui Sun; Antonia Susca; Richard B Todd; Adrian Tsang; Shiela E Unkles; Nathalie van de Wiele; Diana van Rossen-Uffink; Juliana Velasco de Castro Oliveira; Tammi C Vesth; Jaap Visser; Jae-Hyuk Yu; Miaomiao Zhou; Mikael R Andersen; David B Archer; Scott E Baker; Isabelle Benoit; Axel A Brakhage; Gerhard H Braus; Reinhard Fischer; Jens C Frisvad; Gustavo H Goldman; Jos Houbraken; Berl Oakley; István Pócsi; Claudio Scazzocchio; Bernhard Seiboth; Patricia A vanKuyk; Jennifer Wortman; Paul S Dyer; Igor V Grigoriev
Journal:  Genome Biol       Date:  2017-02-14       Impact factor: 13.583

Review 2.  Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018).

Authors:  Jillian Romsdahl; Clay C C Wang
Journal:  Medchemcomm       Date:  2019-04-26       Impact factor: 3.597

3.  Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891.

Authors:  Man-Cheng Tang; Yi Zou; Danielle Yee; Yi Tang
Journal:  AIChE J       Date:  2018-06-11       Impact factor: 3.993

4.  Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi.

Authors:  Alexandra A Soukup; Nancy P Keller; Philipp Wiemann
Journal:  Methods Mol Biol       Date:  2016

5.  Functional Operons in Secondary Metabolic Gene Clusters in Glarea lozoyensis (Fungi, Ascomycota, Leotiomycetes).

Authors:  Qun Yue; Li Chen; Yan Li; Gerald F Bills; Xinyu Zhang; Meichun Xiang; Shaojie Li; Yongsheng Che; Chengshu Wang; Xuemei Niu; Zhiqiang An; Xingzhong Liu
Journal:  MBio       Date:  2015-06-16       Impact factor: 7.867

6.  Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.

Authors:  Xiaoying Bian; Alberto Plaza; Youming Zhang; Rolf Müller
Journal:  Chem Sci       Date:  2015-03-24       Impact factor: 9.825

7.  Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals.

Authors:  Tao Zhang; Jun Wan; Zhajun Zhan; Jian Bai; Bingyu Liu; Youcai Hu
Journal:  Acta Pharm Sin B       Date:  2018-02-03       Impact factor: 11.413

Review 8.  Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei.

Authors:  Jens C Frisvad; Lars L H Møller; Thomas O Larsen; Ravi Kumar; José Arnau
Journal:  Appl Microbiol Biotechnol       Date:  2018-10-06       Impact factor: 4.813

9.  Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli.

Authors:  Sebastian Theobald; Tammi C Vesth; Mikael R Andersen
Journal:  BMC Genomics       Date:  2019-11-13       Impact factor: 3.969

10.  Genome and Metabolome MS-Based Mining of a Marine Strain of Aspergillus affinis.

Authors:  Micael F M Gonçalves; Sandra Hilário; Marta Tacão; Yves Van de Peer; Artur Alves; Ana C Esteves
Journal:  J Fungi (Basel)       Date:  2021-12-18
  10 in total

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