Literature DB >> 2410557

Myxovirus replication in chicken embryos can be suppressed by aprotinin due to the blockage of viral glycoprotein cleavage.

O P Zhirnov, A V Ovcharenko, A G Bukrinskaya.   

Abstract

Injection of the protease inhibitor, aprotinin, into the allantoic cavity of embryonated eggs infected at low m.o.i. with different influenza viruses and paramyxoviruses markedly reduced multiplication by at least 100-fold. Under these conditions, most viral particles produced were non-infectious and contained uncleaved glycoproteins, presumably resulting from aprotinin suppression of protease activity.

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Year:  1985        PMID： 2410557     DOI： 10.1099/0022-1317-66-7-1633

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  14 in total

1.  Antiviral activity of crude extracts from Commiphora swynnertonii against Newcastle disease virus in ovo.

Authors:  Gaymary George Bakari; Robert A Max; Robinson H Mdegela; Elliot C J Phiri; Mkumbukwa M A Mtambo
Journal:  Trop Anim Health Prod       Date:  2012-10       Impact factor: 1.559

2.  The in situ spatial arrangement of the influenza A virus matrix protein M1 assessed by tritium bombardment.

Authors:  A V Shishkov; V I Goldanskii; L A Baratova; N V Fedorova; A L Ksenofontov; O P Zhirnov; A V Galkin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

3.  Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin.

Authors:  Chia-Hsing Leu; Mei-Lin Yang; Nai-Hui Chung; Yen-Jang Huang; Yu-Chu Su; Yi-Cheng Chen; Chia-Cheng Lin; Gia-Shing Shieh; Meng-Ya Chang; Shainn-Wei Wang; Yao Chang; Julie Chao; Lee Chao; Chao-Liang Wu; Ai-Li Shiau
Journal:  Antimicrob Agents Chemother       Date:  2015-07-06       Impact factor: 5.191

4.  Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.

Authors:  Eva Böttcher-Friebertshäuser; Catharina Freuer; Frank Sielaff; Sarah Schmidt; Markus Eickmann; Jennifer Uhlendorff; Torsten Steinmetzer; Hans-Dieter Klenk; Wolfgang Garten
Journal:  J Virol       Date:  2010-03-17       Impact factor: 5.103

5.  Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells.

Authors:  O P Zhirnov; T E Konakova; W Garten; H Klenk
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

6.  Cleavage of influenza a virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases.

Authors:  Oleg P Zhirnov; Mine R Ikizler; Peter F Wright
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

7.  Effects of protease inhibitors on replication of various myxoviruses.

Authors:  M Hosoya; S Matsuyama; M Baba; H Suzuki; S Shigeta
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191

8.  Replication of influenza B virus in chicken embryos is suppressed by exogenous aprotinin.

Authors:  O P Zhirnov; P B Golyando; A V Ovcharenko
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

9.  Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia.

Authors:  Mostafa M Sira; Behairy E Behairy; Azza M Abd-Elaziz; Sameh A Abd Elnaby; Ehab E Eltahan
Journal:  Hepat Res Treat       Date:  2014-09-14

10.  Identification of an aprotinin antiviral domain.

Authors:  A Pellegrini; U Thomas; M Franchini; M Stöckli; S Klauser; P Hunziker; R von Fellenberg
Journal:  FEBS Lett       Date:  1994-05-16       Impact factor: 4.124
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