| Literature DB >> 2410434 |
T Tatsuhara, F Tabuchi, M Unate, Y Okamura, C Shigemasa, K Abe, H Mashiba.
Abstract
A simple and sensitive method for the determination of thiamazole in serum by high-performance liquid chromatography with electrochemical detection is described. Thiamazole in serum was quantified without an extraction procedure at concentrations down to 10 ng/ml. This method was applied to determine the serum concentration of the drug in two healthy volunteers given a single oral dose of 10 mg of thiamazole. The concentration of the drug reached a maximum at 3-4 h after the oral dose and two elimination phases were observed.Entities:
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Year: 1985 PMID： 2410434 DOI： 10.1016/s0378-4347(00)84636-8
Source DB: PubMed Journal: J Chromatogr