Jiin-Ling Jiang1, Shin-Yuan Chen2, Tsung-Cheng Hsieh3, Chi-Wei Lee4, Sheng-Huang Lin5, Sheng-Tzung Tsai6. 1. Department of Nursing, Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. 2. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan; Department of Neurosurgery, Tzu Chi General Hospital, Hualien, Taiwan; Department of Surgery, Tzu Chi University, Hualien, Taiwan; Parkinson's Clinical and Research Center, Tzu Chi General Hospital, Hualien, Taiwan. 3. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. 4. Department of Neurosurgery, Tzu Chi General Hospital, Hualien, Taiwan; Department of Surgery, Tzu Chi University, Hualien, Taiwan. 5. Department of Neurology, Tzu Chi General Hospital, Hualien, Taiwan. 6. Department of Neurosurgery, Tzu Chi General Hospital, Hualien, Taiwan; Department of Surgery, Tzu Chi University, Hualien, Taiwan; Parkinson's Clinical and Research Center, Tzu Chi General Hospital, Hualien, Taiwan. Electronic address: flydream.tsai@gmail.com.
Abstract
BACKGROUND/ PURPOSE: Subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to produce long-term symptom improvement in Parkinson's disease. The aim of this study was to identify the target symptoms that show the most improvement at 1 year and at 5 years after STN-DBS. METHODS: This was a 5-year cohort study of 41 consecutive patients treated with bilateral STN-DBS. Clinical evaluations were performed 1 month prior to surgery and 1 year and 5 years after surgery. The outcome measurements at 1 year and 5 years were the changes compared with the baseline in Unified Parkinson's Disease Rating Scale (UPDRS) parts I, II, III, and IV scores, the Hoehn and Yahr stage, and Schwab and England Activities of Daily Living (SEADL) scores in the conditions of off-medication/on-stimulation and off-medication/off-stimulation. Further analysis included changes in the levodopa equivalent daily dose. RESULTS: When compared to the preoperative baseline off-medication condition, significant improvements were observed in the UPDRS parts I, II, III, and IV and SEADL (p < 0.001) scores in the off-medication/on-stimulation condition 1 year after STN-DBS. Five years after STN-DBS, improvements in UPDRS scores were observed only for parts II, III, and IV (p < 0.001). In the off-medication/off-stimulation condition, no significant improvement was observed. At 5 years, significant deteriorations were observed in scores for the UPDRS part III axial subitem (p = 0.005), UPDRS part I (p = 0.005), UPDRS part II (p < 0.001), and SEADL (p = 0.001). CONCLUSION: The long-term effect of STN-DBS on motor function is promising, although the magnitude of its effectiveness varied over the 5-year period.
BACKGROUND/ PURPOSE: Subthalamic nucleus deep brain stimulation (STN-DBS) has been shown to produce long-term symptom improvement in Parkinson's disease. The aim of this study was to identify the target symptoms that show the most improvement at 1 year and at 5 years after STN-DBS. METHODS: This was a 5-year cohort study of 41 consecutive patients treated with bilateral STN-DBS. Clinical evaluations were performed 1 month prior to surgery and 1 year and 5 years after surgery. The outcome measurements at 1 year and 5 years were the changes compared with the baseline in Unified Parkinson's Disease Rating Scale (UPDRS) parts I, II, III, and IV scores, the Hoehn and Yahr stage, and Schwab and England Activities of Daily Living (SEADL) scores in the conditions of off-medication/on-stimulation and off-medication/off-stimulation. Further analysis included changes in the levodopa equivalent daily dose. RESULTS: When compared to the preoperative baseline off-medication condition, significant improvements were observed in the UPDRS parts I, II, III, and IV and SEADL (p < 0.001) scores in the off-medication/on-stimulation condition 1 year after STN-DBS. Five years after STN-DBS, improvements in UPDRS scores were observed only for parts II, III, and IV (p < 0.001). In the off-medication/off-stimulation condition, no significant improvement was observed. At 5 years, significant deteriorations were observed in scores for the UPDRS part III axial subitem (p = 0.005), UPDRS part I (p = 0.005), UPDRS part II (p < 0.001), and SEADL (p = 0.001). CONCLUSION: The long-term effect of STN-DBS on motor function is promising, although the magnitude of its effectiveness varied over the 5-year period.
Authors: Ondrej Bezdicek; Josef Mana; Filip Růžička; Filip Havlik; Anna Fečíková; Tereza Uhrová; Evžen Růžička; Dušan Urgošík; Robert Jech Journal: Front Aging Neurosci Date: 2022-06-17 Impact factor: 5.702