Qingwei Luo1, Xue Qin Yu, Claire Cooke-Yarborough, David P Smith, Dianne L O'Connell. 1. Cancer Research Division, Cancer Council New South Wales, P.O. Box 572, Kings Cross, NSW 1340, Australia; Sydney School of Public Health, University of Sydney, NSW 2006, Australia. Electronic address: qingweil@nswcc.org.au.
Abstract
BACKGROUND: The New South Wales Central Cancer Registry (NSW CCR) is the only population-based cancer registry in Australia that has routinely collected summary stage at diagnosis since its inception in 1972. However, a large proportion of prostate cancer cases have "unknown" stage recorded by the registry. We investigated the characteristics of prostate cancer cases with "unknown" stage recorded by the NSW CCR, and examined survival for this group. METHODS: Data were obtained from the NSW CCR for all first primary prostate cancer cases diagnosed in 1999-2007. Summary stage was recorded as localised, regional, distant or "unknown". Associations between disease stage and patient characteristics (age, place of residence at diagnosis, year of diagnosis and country of birth) and prostate cancer specific survival were investigated using multivariable logistic regression and Cox proportional hazards models respectively. RESULTS: Of 39852 prostate cancer cases, 41.8% had "unknown" stage recorded by the NSW CCR. This proportion decreased significantly over time, increased with increasing age at diagnosis and was higher for those living in socio-economically disadvantaged areas. The proportion with "unknown" stage varied across area health services. Prostate cancer specific survival for cases with "unknown" stage was significantly poorer than for those with localised stage but better than for those with regional or distant stage. CONCLUSIONS: Researchers or others using cancer registry stage data to examine prostate cancer outcomes need to consider the differences between cases with "unknown" stage at diagnosis and those with known stage recorded by the registry, and what impact this may have on their results.
BACKGROUND: The New South Wales Central Cancer Registry (NSW CCR) is the only population-based cancer registry in Australia that has routinely collected summary stage at diagnosis since its inception in 1972. However, a large proportion of prostate cancer cases have "unknown" stage recorded by the registry. We investigated the characteristics of prostate cancer cases with "unknown" stage recorded by the NSW CCR, and examined survival for this group. METHODS: Data were obtained from the NSW CCR for all first primary prostate cancer cases diagnosed in 1999-2007. Summary stage was recorded as localised, regional, distant or "unknown". Associations between disease stage and patient characteristics (age, place of residence at diagnosis, year of diagnosis and country of birth) and prostate cancer specific survival were investigated using multivariable logistic regression and Cox proportional hazards models respectively. RESULTS: Of 39852 prostate cancer cases, 41.8% had "unknown" stage recorded by the NSW CCR. This proportion decreased significantly over time, increased with increasing age at diagnosis and was higher for those living in socio-economically disadvantaged areas. The proportion with "unknown" stage varied across area health services. Prostate cancer specific survival for cases with "unknown" stage was significantly poorer than for those with localised stage but better than for those with regional or distant stage. CONCLUSIONS: Researchers or others using cancer registry stage data to examine prostate cancer outcomes need to consider the differences between cases with "unknown" stage at diagnosis and those with known stage recorded by the registry, and what impact this may have on their results.
Authors: Suzanne K Chambers; Elizabeth Foley; Samantha Clutton; Robert McDowall; Stefano Occhipinti; Martin Berry; Martin R Stockler; Stephen J Lepore; Mark Frydenberg; Robert A Gardiner; Ian D Davis; David P Smith Journal: Qual Life Res Date: 2016-06-17 Impact factor: 4.147
Authors: Jin Young Choi; Kyoung Eun Yeob; Seung Hwa Hong; So Young Kim; Eun-Hwan Jeong; Dong Wook Shin; Jong Heon Park; Gil-Won Kang; Hak Soon Kim; Jong Hyock Park; Ichiro Kawachi Journal: Cancer Control Date: 2021 Jan-Dec Impact factor: 3.302