AIMS: Most risks of nonsteroidal anti-inflammatory drugs (NSAIDs) are pharmacological, dose and duration dependent. Usage patterns of prescription-only (POM) or 'over-the-counter (OTC)' NSAIDs may influence risks, but are not commonly described. METHODS: The Echantillon Généraliste de Bénéficiaires database, the permanent 1/97 representative sample from the French national healthcare insurance systems, was queried over 2009-2010 to identify usage patterns, concomitant chronic diseases and cardiovascular medication in OTC and POM NSAID users. RESULTS: Over 2 years, 229 477 of 526 108 patients had at least one NSAID dispensation; 44 484 patients (19%) were dispensed only OTC NSAIDs (93% ibuprofen) and 121 208 (53%) only POM NSAIDs. The OTC users were younger (39.9 vs. 47.4 years old) and more often female (57 vs. 53%); 69% of OTC users and 49% of POM users had only one dispensation. A mean of 14.6 defined daily doses (DDD) were dispensed over 2 years for OTC vs. 53 for POM; 93% OTC vs. 60% POM patients bought ≤ 30 DDD over 2 years, and 1.5 vs. 12% bought ≥ 90 DDD. Chronic comorbidities were found in 19% of OTC users vs. 28% of POM users; 24 vs. 37% had at least one dispensation of a cardiovascular drug over the 2 years. CONCLUSIONS: Most of the use of NSAIDs appears to be short term, especially for OTC-type NSAIDs, such as ibuprofen. The validity of risk estimates for NSAIDs extrapolated from clinical trials or from observational studies not including OTC-type usage may need to be revised.
AIMS: Most risks of nonsteroidal anti-inflammatory drugs (NSAIDs) are pharmacological, dose and duration dependent. Usage patterns of prescription-only (POM) or 'over-the-counter (OTC)' NSAIDs may influence risks, but are not commonly described. METHODS: The Echantillon Généraliste de Bénéficiaires database, the permanent 1/97 representative sample from the French national healthcare insurance systems, was queried over 2009-2010 to identify usage patterns, concomitant chronic diseases and cardiovascular medication in OTC and POM NSAID users. RESULTS: Over 2 years, 229 477 of 526 108 patients had at least one NSAID dispensation; 44 484 patients (19%) were dispensed only OTC NSAIDs (93% ibuprofen) and 121 208 (53%) only POM NSAIDs. The OTC users were younger (39.9 vs. 47.4 years old) and more often female (57 vs. 53%); 69% of OTC users and 49% of POM users had only one dispensation. A mean of 14.6 defined daily doses (DDD) were dispensed over 2 years for OTC vs. 53 for POM; 93% OTC vs. 60% POM patients bought ≤ 30 DDD over 2 years, and 1.5 vs. 12% bought ≥ 90 DDD. Chronic comorbidities were found in 19% of OTC users vs. 28% of POM users; 24 vs. 37% had at least one dispensation of a cardiovascular drug over the 2 years. CONCLUSIONS: Most of the use of NSAIDs appears to be short term, especially for OTC-type NSAIDs, such as ibuprofen. The validity of risk estimates for NSAIDs extrapolated from clinical trials or from observational studies not including OTC-type usage may need to be revised.
Authors: Nicholas Moore; Hélène Diris; Karin Martin; Raymond Viale; Annie Fourrier; Yola Moride; Bernard Bégaud Journal: Therapie Date: 2004 Sep-Oct Impact factor: 2.070
Authors: Shelley R Salpeter; Peter Gregor; Thomas M Ormiston; Richard Whitlock; Parminder Raina; Lehana Thabane; Eric J Topol Journal: Am J Med Date: 2006-07 Impact factor: 4.965
Authors: David Laharie; Cécile Droz-Perroteau; Jacques Bénichou; Michel Amouretti; Patrick Blin; Bernard Bégaud; Estelle Guiard; Sylvie Dutoit; Stéphanie Lamarque; Yola Moride; Fanny Depont; Annie Fourrier-Réglat; Nicholas Moore Journal: Br J Clin Pharmacol Date: 2010-03 Impact factor: 4.335
Authors: F E Silverstein; G Faich; J L Goldstein; L S Simon; T Pincus; A Whelton; R Makuch; G Eisen; N M Agrawal; W F Stenson; A M Burr; W W Zhao; J D Kent; J B Lefkowith; K M Verburg; G S Geis Journal: JAMA Date: 2000-09-13 Impact factor: 56.272
Authors: F Salvo; A Fourrier-Réglat; F Bazin; P Robinson; N Riera-Guardia; M Haag; A P Caputi; N Moore; M C Sturkenboom; A Pariente Journal: Clin Pharmacol Ther Date: 2011-04-06 Impact factor: 6.875
Authors: J H Gurwitz; D E Everitt; M Monane; R J Glynn; I Choodnovskiy; M P Beaudet; J Avorn Journal: J Gerontol A Biol Sci Med Sci Date: 1996-03 Impact factor: 6.053
Authors: P Blin; R Lassalle; C Dureau-Pournin; B Ambrosino; M A Bernard; A Abouelfath; H Gin; C Le Jeunne; A Pariente; C Droz; N Moore Journal: Diabetologia Date: 2012-01-06 Impact factor: 10.122
Authors: Mai Duong; Abdelilah Abouelfath; Regis Lassalle; Cécile Droz; Patrick Blin; Nicholas Moore Journal: Drug Saf Date: 2018-11 Impact factor: 5.606