PURPOSE: To describe the visual functions in amblyopia as determinants of response to treatment. METHODS: Sixty-nine patients with unilateral and bilateral amblyopia (114 amblyopic eyes) 3 to 15 years old (mean age: 8.80 ± 2.9 years), 40 males (58%) and 29 females (42%), were included in this study. All patients were treated by conventional occlusion 6 hours per day for mild to moderate amblyopia (visual acuity 0.70 or better) and full-time for 4 weeks followed by 6 hours per day for severe amblyopia (visual acuity 0.8 or worse). During occlusion, near activities requiring hand-eye coordination were advised. The follow-up examination was done at 3 and 6 months. Improvement in visual acuity was evaluated on the logMAR chart and correlated with the visual functions. Statistical analysis was done using Wilcoxon rank sum test (Mann-Whitney U test) and Kruskal-Wallis analysis. RESULTS: There was a statistically significant association of poor contrast sensitivity with the grade of amblyopia (P < .001). The grade of amblyopia (P < .01), accommodation (P < .01), stereopsis (P = .01), and mesopic visual acuity (P < .03) were found to have a correlation with response to amblyopia therapy. CONCLUSIONS: The grade of amblyopia (initial visual acuity) and accommodation are strong determinants of response to amblyopia therapy, whereas stereopsis and mesopic visual acuity have some value as determinants. Copyright 2013, SLACK Incorporated.
PURPOSE: To describe the visual functions in amblyopia as determinants of response to treatment. METHODS: Sixty-nine patients with unilateral and bilateral amblyopia (114 amblyopic eyes) 3 to 15 years old (mean age: 8.80 ± 2.9 years), 40 males (58%) and 29 females (42%), were included in this study. All patients were treated by conventional occlusion 6 hours per day for mild to moderate amblyopia (visual acuity 0.70 or better) and full-time for 4 weeks followed by 6 hours per day for severe amblyopia (visual acuity 0.8 or worse). During occlusion, near activities requiring hand-eye coordination were advised. The follow-up examination was done at 3 and 6 months. Improvement in visual acuity was evaluated on the logMAR chart and correlated with the visual functions. Statistical analysis was done using Wilcoxon rank sum test (Mann-Whitney U test) and Kruskal-Wallis analysis. RESULTS: There was a statistically significant association of poor contrast sensitivity with the grade of amblyopia (P < .001). The grade of amblyopia (P < .01), accommodation (P < .01), stereopsis (P = .01), and mesopic visual acuity (P < .03) were found to have a correlation with response to amblyopia therapy. CONCLUSIONS: The grade of amblyopia (initial visual acuity) and accommodation are strong determinants of response to amblyopia therapy, whereas stereopsis and mesopic visual acuity have some value as determinants. Copyright 2013, SLACK Incorporated.
Authors: Vivian Manh; Angela M Chen; Kristina Tarczy-Hornoch; Susan A Cotter; T Rowan Candy Journal: Invest Ophthalmol Vis Sci Date: 2015-01-27 Impact factor: 4.799