OBJECTIVES: To examine structural integrity loss in the fornix from 5-30 months after moderate and severe traumatic brain injury (TBI) using diffusion tensor imaging. METHODS: MRIs were prospectively undertaken in 29 adults with moderate and severe TBI at two time points. Fractional anisotropy (FA) was calculated for the fornix (column/body, right crux and left crux) at 5 and 30 months post-injury. RESULTS: Paired t-tests revealed significant FA reductions with large effect sizes across time in the column/body, p < 0.001, right crux, p < 0.001 and left crux, p < 0.001. CONCLUSIONS: These data contribute to the growing body of evidence that loss of white matter continues in moderate and severe TBI even after the acute neurological effects of TBI have resolved. As the fornix plays a critical role in memory, this may be a contributing factor to the poor clinical outcomes observed in these patients.
OBJECTIVES: To examine structural integrity loss in the fornix from 5-30 months after moderate and severe traumatic brain injury (TBI) using diffusion tensor imaging. METHODS: MRIs were prospectively undertaken in 29 adults with moderate and severe TBI at two time points. Fractional anisotropy (FA) was calculated for the fornix (column/body, right crux and left crux) at 5 and 30 months post-injury. RESULTS: Paired t-tests revealed significant FA reductions with large effect sizes across time in the column/body, p < 0.001, right crux, p < 0.001 and left crux, p < 0.001. CONCLUSIONS: These data contribute to the growing body of evidence that loss of white matter continues in moderate and severe TBI even after the acute neurological effects of TBI have resolved. As the fornix plays a critical role in memory, this may be a contributing factor to the poor clinical outcomes observed in these patients.
Authors: Hannah M Lindsey; Sanam J Lalani; Jonathan Mietchen; Shawn D Gale; Elisabeth A Wilde; Jessica Faber; Marianne C MacLeod; Jill V Hunter; Zili D Chu; Mary E Aitken; Linda Ewing-Cobbs; Harvey S Levin Journal: Brain Imaging Behav Date: 2020-10 Impact factor: 3.978
Authors: Jennifer C Tomaszczyk; Nathaniel L Green; Diana Frasca; Brenda Colella; Gary R Turner; Bruce K Christensen; Robin E A Green Journal: Neuropsychol Rev Date: 2014-11-25 Impact factor: 7.444
Authors: Nikos Konstantinou; Eva Pettemeridou; Ioannis Seimenis; Eleni Eracleous; Savvas S Papacostas; Andrew C Papanicolaou; Fofi Constantinidou Journal: Front Neurol Date: 2016-03-10 Impact factor: 4.003
Authors: Lesley S Miller; Brenda Colella; David Mikulis; Jerome Maller; Robin E A Green Journal: Front Hum Neurosci Date: 2013-09-24 Impact factor: 3.169
Authors: Maria Carmela Tartaglia; Lili-Naz Hazrati; Karen D Davis; Robin E A Green; Richard Wennberg; David Mikulis; Leo J Ezerins; Michelle Keightley; Charles Tator Journal: Front Hum Neurosci Date: 2014-01-31 Impact factor: 3.169
Authors: Robin E A Green; Brenda Colella; Jerome J Maller; Mark Bayley; Joanna Glazer; David J Mikulis Journal: Front Hum Neurosci Date: 2014-03-31 Impact factor: 3.169