Literature DB >> 24101648

A national cholera epidemic with high case fatality rates--Kenya 2009.

Anagha Loharikar1, Elizabeth Briere, Maurice Ope, Daniel Langat, Ian Njeru, Lucy Gathigi, Lyndah Makayotto, Abdirizak M Ismail, Martin Thuranira, Ahmed Abade, Samuel Amwayi, Jared Omolo, Joe Oundo, Kevin M De Cock, Robert F Breiman, Tracy Ayers, Eric Mintz, Ciara E O'Reilly.   

Abstract

BACKGROUND: Cholera remains endemic in sub-Saharan Africa. We characterized the 2009 cholera outbreaks in Kenya and evaluated the response.
METHODS: We analyzed surveillance data and estimated case fatality rates (CFRs). Households in 2 districts, East Pokot (224 cases; CFR = 11.7%) and Turkana South (1493 cases; CFR = 1.0%), were surveyed. We randomly selected 15 villages and 8 households per village in each district. Healthcare workers at 27 health facilities (HFs) were surveyed in both districts.
RESULTS: In 2009, cholera outbreaks caused a reported 11 425 cases and 264 deaths in Kenya. Data were available from 44 districts for 6893 (60%) cases. District CFRs ranged from 0% to 14.3%. Surveyed household respondents (n = 240) were aware of cholera (97.5%) and oral rehydration solution (ORS) (87.9%). Cholera deaths were reported more frequently from East Pokot (n = 120) than Turkana South (n = 120) households (20.7% vs. 12.3%). The average travel time to a HF was 31 hours in East Pokot compared with 2 hours in Turkana South. Fewer respondents in East Pokot (9.8%) than in Turkana South (33.9%) stated that ORS was available in their village. ORS or intravenous fluid shortages occurred in 20 (76.9%) surveyed HFs.
CONCLUSIONS: High CFRs in Kenya are related to healthcare access disparities, including availability of rehydration supplies.

Entities:  

Keywords:  Kenya; cholera; nomadic/semi-pastoral; outbreak; sanitation; water

Mesh:

Year:  2013        PMID: 24101648     DOI: 10.1093/infdis/jit220

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  9 in total

1.  Utilization of Small RNA Genes to Distinguish Vibrio cholerae Biotypes via Multiplex Polymerase Chain Reaction.

Authors:  Siti Aminah Ahmed; Carsten A Raabe; Hong Leong Cheah; Chee Hock Hoe; Timofey S Rozhdestvensky; Thean Hock Tang
Journal:  Am J Trop Med Hyg       Date:  2019-06       Impact factor: 2.345

2.  Cumulative protective efficacy of rZot and rAce combination in challenge experiments with wild type Vibrio cholerae in mouse model.

Authors:  Shaghayegh Anvari; Shahin Najar-Peerayeh; Mehrdad Behmanesh; Bita Bakhshi
Journal:  Hum Vaccin Immunother       Date:  2018-06-19       Impact factor: 3.452

3.  A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.

Authors:  Kevin Y H Liang; Fabini D Orata; Mohammad Tarequl Islam; Tania Nasreen; Munirul Alam; Cheryl L Tarr; Yann F Boucher
Journal:  J Bacteriol       Date:  2020-11-19       Impact factor: 3.490

4.  Evaluation of targeted mass cholera vaccination strategies in Bangladesh: a demonstration of a new cost-effectiveness calculator.

Authors:  Christopher Troeger; David A Sack; Dennis L Chao
Journal:  Am J Trop Med Hyg       Date:  2014-10-06       Impact factor: 2.345

5.  Interaction between climatic, environmental, and demographic factors on cholera outbreaks in Kenya.

Authors:  James D Stoltzfus; Jane Y Carter; Muge Akpinar-Elci; Martin Matu; Victoria Kimotho; Mark J Giganti; Daniel Langat; Omur Cinar Elci
Journal:  Infect Dis Poverty       Date:  2014-10-01       Impact factor: 4.520

Review 6.  Cholera prevention and control in refugee settings: Successes and continued challenges.

Authors:  Kerry Shannon; Marisa Hast; Andrew S Azman; Dominique Legros; Heather McKay; Justin Lessler
Journal:  PLoS Negl Trop Dis       Date:  2019-06-20

7.  Factors associated with cholera in Kenya, 2008-2013.

Authors:  Gretchen Cowman; Shikanga Otipo; Ian Njeru; Thomas Achia; Harsha Thirumurthy; Jamie Bartram; Jackson Kioko
Journal:  Pan Afr Med J       Date:  2017-10-03

8.  Systems, supplies, and staff: a mixed-methods study of health care workers' experiences and health facility preparedness during a large national cholera outbreak, Kenya 2015.

Authors:  Kathryn G Curran; Emma Wells; Samuel J Crowe; Rupa Narra; Jared Oremo; Waqo Boru; Jane Githuku; Mark Obonyo; Kevin M De Cock; Joel M Montgomery; Lyndah Makayotto; Daniel Langat; Sara A Lowther; Ciara O'Reilly; Zeinab Gura; Jackson Kioko
Journal:  BMC Public Health       Date:  2018-06-11       Impact factor: 3.295

9.  A protracted cholera outbreak among residents in an urban setting, Nairobi county, Kenya, 2015.

Authors:  Hudson Taabukk Kigen; Waqo Boru; Zeinab Gura; George Githuka; Robert Mulembani; Jacob Rotich; Isack Abdi; Tura Galgalo; Jane Githuku; Mark Obonyo; Raphael Muli; Ian Njeru; Daniel Langat; Peter Nsubuga; Jackson Kioko; Sara Lowther
Journal:  Pan Afr Med J       Date:  2020-06-25
  9 in total

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