BACKGROUND: Impaired sleep enhances pain, perhaps by disrupting pain modulation. PURPOSE: Given that emotion modulates pain, the present study examined whether emotional modulation of pain and nociception is impaired in persons with severe insomnia symptoms relative to controls. METHODS: Insomnia group (n = 12) met the International Classification of Diseases, tenth revision symptoms for primary insomnia and controls (n = 13) reported no sleep impairment. Participants were shown emotionally evocative pictures (mutilation, neutral, and erotica) during which suprathreshold pain stimuli were delivered to evoke pain and the nociceptive flexion reflex (NFR; physiological correlate of spinal nociception). RESULTS: Emotional responses to pictures were similar in both groups, except that subjective valence/pleasure ratings were blunted in insomnia. Emotional modulation of pain and NFR was observed in controls, but only emotional modulation of NFR was observed in insomnia. CONCLUSIONS: Consistent with previous findings, pain modulation is disrupted in insomnia, which might promote pain. This may stem from disrupted supraspinal circuits not disrupted brain-to-spinal cord circuits.
BACKGROUND: Impaired sleep enhances pain, perhaps by disrupting pain modulation. PURPOSE: Given that emotion modulates pain, the present study examined whether emotional modulation of pain and nociception is impaired in persons with severe insomnia symptoms relative to controls. METHODS:Insomnia group (n = 12) met the International Classification of Diseases, tenth revision symptoms for primary insomnia and controls (n = 13) reported no sleep impairment. Participants were shown emotionally evocative pictures (mutilation, neutral, and erotica) during which suprathreshold pain stimuli were delivered to evoke pain and the nociceptive flexion reflex (NFR; physiological correlate of spinal nociception). RESULTS: Emotional responses to pictures were similar in both groups, except that subjective valence/pleasure ratings were blunted in insomnia. Emotional modulation of pain and NFR was observed in controls, but only emotional modulation of NFR was observed in insomnia. CONCLUSIONS: Consistent with previous findings, pain modulation is disrupted in insomnia, which might promote pain. This may stem from disrupted supraspinal circuits not disrupted brain-to-spinal cord circuits.
Authors: Megan E Petrov; Burel R Goodin; Yenisel Cruz-Almeida; Chris King; Toni L Glover; Hailey W Bulls; Matthew Herbert; Kimberly T Sibille; Emily J Bartley; Barri J Fessler; Adriana Sotolongo; Roland Staud; David Redden; Roger B Fillingim; Laurence A Bradley Journal: J Pain Date: 2015-02-25 Impact factor: 5.820
Authors: Natalie Hellman; Bethany L Kuhn; Edward W Lannon; Michael F Payne; Cassandra A Sturycz; Shreela Palit; Joanna O Shadlow; Jamie L Rhudy Journal: Psychosom Med Date: 2018 Nov/Dec Impact factor: 4.312
Authors: Patrick H Finan; Phillip J Quartana; Bethany Remeniuk; Eric L Garland; Jamie L Rhudy; Matthew Hand; Michael R Irwin; Michael T Smith Journal: Sleep Date: 2017-01-01 Impact factor: 5.849
Authors: Cassandra A Sturycz; Natalie Hellman; Michael F Payne; Bethany L Kuhn; Burkhart Hahn; Edward W Lannon; Shreela Palit; Yvette M Güereca; Tyler A Toledo; Joanna O Shadlow; Jamie L Rhudy Journal: J Pain Date: 2019-02-15 Impact factor: 5.820
Authors: Natalie Hellman; Cassandra A Sturycz; Edward W Lannon; Bethany L Kuhn; Yvette M Güereca; Tyler A Toledo; Michael F Payne; Felicitas A Huber; Mara Demuth; Shreela Palit; Joanna O Shadlow; Jamie L Rhudy Journal: J Pain Date: 2019-02-27 Impact factor: 5.820
Authors: E Danielle; R N Fox; Natalie Wiebe; Danielle A Southern; Hude Quan; Ellena Kim; Chris King; Olga Grosu; Cathy A Eastwood Journal: Perspect Health Inf Manag Date: 2021-07-01
Authors: Lliure-Naima Mory; Daniel de Oliveira Fernandes; Christian Mancini; Michael Mouthon; Joelle Nsimire Chabwine Journal: J Clin Med Date: 2022-06-08 Impact factor: 4.964
Authors: Shreela Palit; Emily J Bartley; Bethany L Kuhn; Kara L Kerr; Jennifer L DelVentura; Ellen L Terry; Jamie L Rhudy Journal: J Pain Res Date: 2016-02-11 Impact factor: 3.133