Literature DB >> 24100980

Akt2 relaxes podocytes in chronic kidney disease.

Jochen Reiser1.   

Abstract

A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).

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Year:  2013        PMID: 24100980     DOI: 10.1038/nm.3357

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  12 in total

Review 1.  mTOR inhibitor-associated proteinuria in kidney transplant recipients.

Authors:  Fritz Diekmann; Amado Andrés; Federico Oppenheimer
Journal:  Transplant Rev (Orlando)       Date:  2012-01       Impact factor: 3.943

Review 2.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

3.  AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.

Authors:  Guillaume Canaud; Frank Bienaimé; Amandine Viau; Caroline Treins; William Baron; Clément Nguyen; Martine Burtin; Sophie Berissi; Konstantinos Giannakakis; Andrea Onetti Muda; Stefan Zschiedrich; Tobias B Huber; Gérard Friedlander; Christophe Legendre; Marco Pontoglio; Mario Pende; Fabiola Terzi
Journal:  Nat Med       Date:  2013-09-22       Impact factor: 53.440

4.  CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.

Authors:  Suma Yaddanapudi; Mehmet M Altintas; Andreas D Kistler; Isabel Fernandez; Clemens C Möller; Changli Wei; Vasil Peev; Jan B Flesche; Anna-Lena Forst; Jing Li; Jaakko Patrakka; Zhijie Xiao; Florian Grahammer; Mario Schiffer; Tobias Lohmüller; Thomas Reinheckel; Changkyu Gu; Tobias B Huber; Wenjun Ju; Markus Bitzer; Maria P Rastaldi; Phillip Ruiz; Karl Tryggvason; Andrey S Shaw; Christian Faul; Sanja Sever; Jochen Reiser
Journal:  J Clin Invest       Date:  2011-09-12       Impact factor: 14.808

5.  Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.

Authors:  Markus Gödel; Björn Hartleben; Nadja Herbach; Shuya Liu; Stefan Zschiedrich; Shun Lu; Andrea Debreczeni-Mór; Maja T Lindenmeyer; Maria-Pia Rastaldi; Götz Hartleben; Thorsten Wiech; Alessia Fornoni; Robert G Nelson; Matthias Kretzler; Rüdiger Wanke; Hermann Pavenstädt; Dontscho Kerjaschki; Clemens D Cohen; Michael N Hall; Markus A Rüegg; Ken Inoki; Gerd Walz; Tobias B Huber
Journal:  J Clin Invest       Date:  2011-05-23       Impact factor: 14.808

Review 6.  Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease.

Authors:  Miki Nagase; Toshiro Fujita
Journal:  Nat Rev Nephrol       Date:  2013-01-08       Impact factor: 28.314

7.  Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

Authors:  Dos D Sarbassov; Siraj M Ali; Shomit Sengupta; Joon-Ho Sheen; Peggy P Hsu; Alex F Bagley; Andrew L Markhard; David M Sabatini
Journal:  Mol Cell       Date:  2006-04-06       Impact factor: 17.970

8.  Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells.

Authors:  Shinsuke Nozaki; Tomoya Takeda; Takuya Kitaura; Nobuyuki Takenaka; Tohru Kataoka; Takaya Satoh
Journal:  Cell Signal       Date:  2013-03-14       Impact factor: 4.315

Review 9.  Podocyte biology and pathogenesis of kidney disease.

Authors:  Jochen Reiser; Sanja Sever
Journal:  Annu Rev Med       Date:  2012-11-26       Impact factor: 13.739

10.  Podocyte GTPases regulate kidney filter dynamics.

Authors:  Andreas D Kistler; Mehmet M Altintas; Jochen Reiser
Journal:  Kidney Int       Date:  2012-06       Impact factor: 10.612

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  4 in total

1.  Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.

Authors:  Yao Yao; Junying Wang; Sei Yoshida; Shigeyuki Nada; Masato Okada; Ken Inoki
Journal:  J Am Soc Nephrol       Date:  2016-03-31       Impact factor: 10.121

Review 2.  Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy.

Authors:  Stacy A Johnson; Robert F Spurney
Journal:  Am J Physiol Renal Physiol       Date:  2015-09-02

3.  An in vitro model of renal inflammation after ischemic oxidative stress injury: nephroprotective effects of a hyaluronan ester with butyric acid on mesangial cells.

Authors:  Olga Baraldi; Francesca Bianchi; Viola Menghi; Andrea Angeletti; Anna Laura Croci Chiocchini; Maria Cappuccilli; Valeria Aiello; Giorgia Comai; Gaetano La Manna
Journal:  J Inflamm Res       Date:  2017-09-08

4.  Induction monotherapy with sirolimus has selected beneficial effects on glomerular and tubulointersititial injury in nephrotoxic serum nephritis.

Authors:  Lena Succar; Julia Lai-Kwon; David J Nikolic-Paterson; Gopala K Rangan
Journal:  Int J Nephrol Renovasc Dis       Date:  2014-07-18
  4 in total

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