Jakob Begun1, Ramnik J Xavier. 1. aGastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts bBroad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Abstract
PURPOSE OF REVIEW: From its initial description as a homeostatic process required for starvation response, autophagy has emerged as a ubiquitous cellular process involved in a broad range of cellular activities from metabolic adaptation to cellular defense against invading pathogens. This review provides an overview of autophagy and highlights the recent developments in deciphering its role in metabolic adaptation and its importance in antibacterial defense with attention to regulatory pathways. RECENT FINDINGS: Within the last 2 years, there has been significant progress in deciphering the mechanisms by which autophagy is regulated, including subcellular localization, posttranslational modifications, and transcriptional control. In addition, the cell type-specific role of autophagy in maintaining cellular homeostasis has been defined, including its role in handling intracellular pathogens and its contribution to inflammatory bowel disease. SUMMARY: Autophagy is a critical pathway that integrates numerous regulatory inputs to maintain cellular homeostasis and defend against intracellular pathogens.
PURPOSE OF REVIEW: From its initial description as a homeostatic process required for starvation response, autophagy has emerged as a ubiquitous cellular process involved in a broad range of cellular activities from metabolic adaptation to cellular defense against invading pathogens. This review provides an overview of autophagy and highlights the recent developments in deciphering its role in metabolic adaptation and its importance in antibacterial defense with attention to regulatory pathways. RECENT FINDINGS: Within the last 2 years, there has been significant progress in deciphering the mechanisms by which autophagy is regulated, including subcellular localization, posttranslational modifications, and transcriptional control. In addition, the cell type-specific role of autophagy in maintaining cellular homeostasis has been defined, including its role in handling intracellular pathogens and its contribution to inflammatory bowel disease. SUMMARY: Autophagy is a critical pathway that integrates numerous regulatory inputs to maintain cellular homeostasis and defend against intracellular pathogens.
Authors: William E Dowdle; Beat Nyfeler; Jane Nagel; Robert A Elling; Shanming Liu; Ellen Triantafellow; Suchithra Menon; Zuncai Wang; Ayako Honda; Gwynn Pardee; John Cantwell; Catherine Luu; Ivan Cornella-Taracido; Edmund Harrington; Peter Fekkes; Hong Lei; Qing Fang; Mary Ellen Digan; Debra Burdick; Andrew F Powers; Stephen B Helliwell; Simon D'Aquin; Julie Bastien; Henry Wang; Dmitri Wiederschain; Jenny Kuerth; Philip Bergman; David Schwalb; Jason Thomas; Savuth Ugwonali; Fred Harbinski; John Tallarico; Christopher J Wilson; Vic E Myer; Jeffery A Porter; Dirksen E Bussiere; Peter M Finan; Mark A Labow; Xiaohong Mao; Lawrence G Hamann; Brendan D Manning; Reginald A Valdez; Thomas Nicholson; Markus Schirle; Mark S Knapp; Erin P Keaney; Leon O Murphy Journal: Nat Cell Biol Date: 2014-10-19 Impact factor: 28.824
Authors: E N Ngoh; H K Brugger; M Monajemi; S C Menzies; A F Hirschfeld; K L Del Bel; K Jacobson; P M Lavoie; S E Turvey; L M Sly Journal: Genes Immun Date: 2015-07-30 Impact factor: 2.676
Authors: Christina H Eng; Zuncai Wang; Diane Tkach; Lourdes Toral-Barza; Savuth Ugwonali; Shanming Liu; Stephanie L Fitzgerald; Elizabeth George; Elizabeth Frias; Nadire Cochran; Rowena De Jesus; Gregory McAllister; Gregory R Hoffman; Kevin Bray; LuAnna Lemon; Judy Lucas; Valeria R Fantin; Robert T Abraham; Leon O Murphy; Beat Nyfeler Journal: Proc Natl Acad Sci U S A Date: 2015-12-17 Impact factor: 11.205
Authors: I Oancea; R Movva; I Das; D Aguirre de Cárcer; V Schreiber; Y Yang; A Purdon; B Harrington; M Proctor; R Wang; Y Sheng; M Lobb; R Lourie; P Ó Cuív; J A Duley; J Begun; T H J Florin Journal: Gut Date: 2016-07-13 Impact factor: 23.059