| Literature DB >> 24100633 |
Logan Dumitrescu1, Cara L Carty, Nora Franceschini, Lucia A Hindorff, Shelley A Cole, Petra Bůžková, Fredrick R Schumacher, Charles B Eaton, Robert J Goodloe, David J Duggan, Jeff Haessler, Barbara Cochran, Brian E Henderson, Iona Cheng, Karen C Johnson, Chris S Carlson, Shelly-Anne Love, Kristin Brown-Gentry, Alejandro Q Nato, Miguel Quibrera, Ralph V Shohet, José Luis Ambite, Lynne R Wilkens, Loïc Le Marchand, Christopher A Haiman, Steven Buyske, Charles Kooperberg, Kari E North, Myriam Fornage, Dana C Crawford.
Abstract
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.Entities:
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Year: 2013 PMID： 24100633 PMCID： PMC3895337 DOI： 10.1007/s00439-013-1375-3
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132