Literature DB >> 24099984

EBNA-1 IgG titers in Sardinian multiple sclerosis patients and controls.

Giuseppe Mameli1, Davide Cossu, Eleonora Cocco, Speranza Masala, Jessica Frau, Maria Giovanna Marrosu, Leonardo A Sechi.   

Abstract

Multiple sclerosis (MS) is thought to be triggered by environmental factors acting on a genetic predisposition. Sardinians share a homogeneous genetic background and boast one of the highest MS prevalence worldwide. We investigated Epstein-Barr virus (EBV) antibody prevalence in Sardinian population by ELISA. Our results show a higher serum prevalence of EBNA-1 IgG in MS patients compared to healthy controls. Moreover, analyzing a subset of patients treated for 6 months with IFN-β, we observed a decrease in their EBNA-1 specific IgG titers. These results confirm previous findings and strengthen the association between EBV and MS in Sardinia.
© 2013.

Entities:  

Keywords:  EBNA-1; Epstein–Barr virus; IFN-β; Multiple sclerosis; Sardinian

Mesh：

Substances：

Year:  2013        PMID： 24099984     DOI： 10.1016/j.jneuroim.2013.07.017

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  12 in total

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Review 10.  Infections and Multiple Sclerosis: From the World to Sardinia, From Sardinia to the World.

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