Literature DB >> 24099863

Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.

Varykina G Thackray1.   

Abstract

Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced by pituitary gonadotrope cells and are required for steroidogenesis, the maturation of ovarian follicles, ovulation, and spermatogenesis. Synthesis of LH and FSH is tightly regulated by a complex network of signaling pathways activated by hormones including gonadotropin-releasing hormone, activin and sex steroids. Members of the forkhead box (FOX) transcription factor family have been shown to act as important regulators of development, homeostasis and reproduction. In this review, we focus on the role of four specific FOX factors (FOXD1, FOXL2, FOXO1 and FOXP3) in gonadotropin hormone production and discuss our current understanding of the molecular function of these factors derived from studies in mouse genetic and cell culture models.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Follicle-stimulating hormone; Forkhead; Gonadotrope; Luteinizing hormone; Pituitary; Transcription

Mesh：

Substances：

Year:  2013        PMID： 24099863      PMCID： PMC3947687          DOI： 10.1016/j.mce.2013.09.034

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  111 in total

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