Charlotte Rosso1, R Valabregue2, C Arbizu3, S Ferrieux4, P Vargas5, F Humbert2, Y Attal5, A Messé6, C Zavanone7, S Meunier8, L Cohen9, C Delmaire10, A Thielscher11, D M Herz12, H R Siebner12, Y Samson13, S Lehéricy14. 1. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; COGIMAGE, UPMC Paris 6, Paris, France; APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France; Univ Paris 11, IFR49, DSV/I2BM/NeuroSpin, Bat 145, Gif-sur-Yvette 91191, France. Electronic address: charlotte.rosso@gmail.com. 2. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; Institut du Cerveau et de la Moelle épinière, Centre de Neuro-Imagerie de Recherche (CENIR), Paris, France. 3. APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France; Centre des Maladies Cognitives et Comportementales, IM2A, Hôpital Pitié-Salpêtrière, Paris, France. 4. Centre des Maladies Cognitives et Comportementales, IM2A, Hôpital Pitié-Salpêtrière, Paris, France; APHP, Service de Soins de Suites et Réadaptation, Hôpital Pitié-Salpêtrière, Paris, France. 5. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; COGIMAGE, UPMC Paris 6, Paris, France. 6. Univ Paris 11, IFR49, DSV/I2BM/NeuroSpin, Bat 145, Gif-sur-Yvette 91191, France; Inserm, UPMC Univ Paris 06, UMRS 678, Laboratoire d'Imagerie Fonctionnelle, Paris, France. 7. APHP, Service de Soins de Suites et Réadaptation, Hôpital Pitié-Salpêtrière, Paris, France. 8. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; Institut du Cerveau et de la Moelle épinière, Movement Disorders and Basal Ganglia: Pathophysiology and Experimental Therapeutics, Paris, France. 9. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; COGIMAGE, UPMC Paris 6, Paris, France; Neuropsychologie et Neuroimagerie, UPMC Paris 6, Paris, France. 10. Neuroradiology Department, CHRU Roger Salengro, Lille, France. 11. Danish Research Centre for Magnetic Resonance, University Hospital Copenhagen, Hvidovre, Denmark; Danish Technical University, Kgs. Lyngby, Denmark; MPI for Biological Cybernetics, Tübingen, Germany. 12. Danish Research Centre for Magnetic Resonance, University Hospital Copenhagen, Hvidovre, Denmark. 13. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; COGIMAGE, UPMC Paris 6, Paris, France; APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France. 14. CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Paris, France; Inserm, U975, CNRS, UMR 7225 Paris, France; Institut du Cerveau et de la Moelle épinière, Centre de Neuro-Imagerie de Recherche (CENIR), Paris, France; APHP, Service de Neuroradiologie, Hôpital Pitié-Salpêtrière, Paris, France.
Abstract
BACKGROUND: Cathodal transcranial direct current stimulation (tDCS) of the right frontal cortex improves language abilities in post-stroke aphasic patients. Yet little is known about the effects of right frontal cathodal tDCS on normal language function. OBJECTIVE/HYPOTHESIS: To explore the cathodal tDCS effects of the right-hemispheric homologue of Broca's area on picture naming in healthy individuals. We hypothesized that cathodal tDCS improves picture naming and that this effect is determined by the anatomical and functional connectivity of the targeted region. METHODS: Cathodal and sham tDCS were applied to the right inferior frontal gyrus in 24 healthy subjects before a picture-naming task. All participants were studied with magnetic resonance imaging at pre-interventional baseline. Probabilistic tractography and dynamic causal modeling of functional brain activity during a word repetition task were applied to characterize anatomical and functional connectivity. RESULTS: Subjects named pictures faster after cathodal relative to sham tDCS. The accelerating effect of tDCS was explained by a reduced frequency of very slow responses. tDCS-induced acceleration of picture naming correlated with larger volumes of the tract connecting the right Broca's area and the supplementary motor area (SMA) and greater functional coupling from the right SMA to the right Broca's area. CONCLUSIONS: The results support the notion that the after-effects of tDCS on brain function are at least in part determined by the anatomical and functional connectivity of the targeted region.
BACKGROUND: Cathodal transcranial direct current stimulation (tDCS) of the right frontal cortex improves language abilities in post-stroke aphasic patients. Yet little is known about the effects of right frontal cathodal tDCS on normal language function. OBJECTIVE/HYPOTHESIS: To explore the cathodal tDCS effects of the right-hemispheric homologue of Broca's area on picture naming in healthy individuals. We hypothesized that cathodal tDCS improves picture naming and that this effect is determined by the anatomical and functional connectivity of the targeted region. METHODS: Cathodal and sham tDCS were applied to the right inferior frontal gyrus in 24 healthy subjects before a picture-naming task. All participants were studied with magnetic resonance imaging at pre-interventional baseline. Probabilistic tractography and dynamic causal modeling of functional brain activity during a word repetition task were applied to characterize anatomical and functional connectivity. RESULTS: Subjects named pictures faster after cathodal relative to sham tDCS. The accelerating effect of tDCS was explained by a reduced frequency of very slow responses. tDCS-induced acceleration of picture naming correlated with larger volumes of the tract connecting the right Broca's area and the supplementary motor area (SMA) and greater functional coupling from the right SMA to the right Broca's area. CONCLUSIONS: The results support the notion that the after-effects of tDCS on brain function are at least in part determined by the anatomical and functional connectivity of the targeted region.
Authors: Theodore P Zanto; Kevin T Jones; Avery E Ostrand; Wan-Yu Hsu; Richard Campusano; Adam Gazzaley Journal: Brain Stimul Date: 2021-09-01 Impact factor: 9.184
Authors: Roozbeh Behroozmand; Nadine Ibrahim; Oleg Korzyukov; Donald A Robin; Charles R Larson Journal: Front Neurosci Date: 2015-03-31 Impact factor: 4.677
Authors: Ellen W S Carbo; Arjan Hillebrand; Edwin van Dellen; Prejaas Tewarie; Philip C de Witt Hamer; Johannes C Baayen; Martin Klein; Jeroen J G Geurts; Jaap C Reijneveld; Cornelis J Stam; Linda Douw Journal: Sci Rep Date: 2017-02-07 Impact factor: 4.379
Authors: Ronaldo Luis da Silva; David Labrecque; Fátima Aparecida Caromano; Johanne Higgins; Victor Frak Journal: PLoS One Date: 2018-02-05 Impact factor: 3.240