Literature DB >> 2409970

Modulation of cyclic AMP accumulation in GH3 cells by a phorbol ester and thyroliberin.

L A Quilliam, P R Dobson, B L Brown.   

Abstract

4 beta phorbol-12, 13-dibutyrate (PDBu) stimulated cyclic AMP accumulation in GH3 pituitary tumour cells in the presence of isobutylmethylxanthine. This effect persisted after preincubation of cells with cholera or pertussis toxins. In contrast, vasoactive intestinal polypeptide (VIP)-stimulated cyclic AMP accumulation was inhibited by PDBu in a dose dependent fashion (IC50 = 5.1 nM). Thyroliberin (TRH) had a similar, but non-additive, stimulatory effect on cyclic AMP accumulation with PDBu, however it did not inhibit VIP stimulation. These results suggest that TRH may stimulate cyclic AMP accumulation through protein kinase C and that stimulation of adenylate cyclase by PDBu and TRH may occur distal to the guanine nucleotide binding regulatory proteins, Ns and Ni.

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Year:  1985        PMID： 2409970     DOI： 10.1016/0006-291x(85)91976-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets.

Authors:  K A Williams; W Murphy; R J Haslam
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

2.  The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism.

Authors:  G J Murphy; V J Hruby; D Trivedi; M J Wakelam; M D Houslay
Journal:  Biochem J       Date:  1987-04-01       Impact factor: 3.857

3.  Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells.

Authors:  Y Fukushima; T Asano; H Katagiri; M Aihara; T Saitoh; M Anai; M Funaki; T Ogihara; K Inukai; N Matsuhashi; Y Oka; Y Yazaki; K Sugano
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

4.  Beta-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth.

Authors:  J S Karliner; P C Simpson
Journal:  Basic Res Cardiol       Date:  1988 Nov-Dec       Impact factor: 17.165

5.  Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C.

Authors:  L A Quilliam; P R Dobson; B L Brown
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

6.  AMPK Activation of Apoptotic Markers in Human Breast Cancer Cell Lines with Different p53 Backgrounds: MCF-7, MDA-MB-231 and T47D Cells.

Authors:  Omar S El-Masry; Barry L Brown; Pauline R M Dobson
Journal:  Asian Pac J Cancer Prev       Date:  2019-12-01
  6 in total

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