PURPOSE: The aim of this study was to evaluate the long-term cognitive outcome in children with continuous spikes and waves during slow wave sleep (CSWS syndrome). METHODS: We reviewed the neuropsychological tests of 25 children diagnosed with CSWS between 1987 and 2010 and with a mean follow-up of 13.5 years. KEY FINDINGS: Cognitive performances worsened during CSWS in virtually all patients. Seven patients (28%) with nonlesional epilepsy had a positive outcome; three patients (12%) showed persistence of motor deficit without involvement of cognitive functions; and seven patients (28%) who presented a long duration of CSWS (mean = 28.1 months) had a negative cognitive outcome. In 6 patients (24%) with structural or metabolic disorders before CSWS onset cognitive outcomes did not change; 2 patients (8%) had a negative outcome irrespective of the duration or presence of other neurologic disorders before CSWS onset. Forty-four percent of children with CSWS demonstrated permanent cognitive impairment. SIGNIFICANCE: The long-term outcome of CSWS syndrome is variable and seems to depend on treatment response, disease duration, and underlying etiology. Wiley Periodicals, Inc.
PURPOSE: The aim of this study was to evaluate the long-term cognitive outcome in children with continuous spikes and waves during slow wave sleep (CSWS syndrome). METHODS: We reviewed the neuropsychological tests of 25 children diagnosed with CSWS between 1987 and 2010 and with a mean follow-up of 13.5 years. KEY FINDINGS: Cognitive performances worsened during CSWS in virtually all patients. Seven patients (28%) with nonlesional epilepsy had a positive outcome; three patients (12%) showed persistence of motor deficit without involvement of cognitive functions; and seven patients (28%) who presented a long duration of CSWS (mean = 28.1 months) had a negative cognitive outcome. In 6 patients (24%) with structural or metabolic disorders before CSWS onset cognitive outcomes did not change; 2 patients (8%) had a negative outcome irrespective of the duration or presence of other neurologic disorders before CSWS onset. Forty-four percent of children with CSWS demonstrated permanent cognitive impairment. SIGNIFICANCE: The long-term outcome of CSWS syndrome is variable and seems to depend on treatment response, disease duration, and underlying etiology. Wiley Periodicals, Inc.
Authors: Julia Jacobs; Antonia Menzel; Georgia Ramantani; Katharina Körbl; Jakob Assländer; Andreas Schulze-Bonhage; Jürgen Hennig; Pierre LeVan Journal: Front Neurosci Date: 2014-11-18 Impact factor: 4.677
Authors: Bart van den Munckhof; Alexis Arzimanoglou; Emilio Perucca; Heleen C van Teeseling; Frans S S Leijten; Kees P J Braun; Floor E Jansen Journal: Trials Date: 2020-11-23 Impact factor: 2.279
Authors: Bart van den Munckhof; Anne F Zwart; Lauren C Weeke; Nathalie H P Claessens; Joost D J Plate; Alexander Leemans; Hugo J Kuijf; Heleen C van Teeseling; Frans S S Leijten; Manon J N Benders; Kees P J Braun; Linda S de Vries; Floor E Jansen Journal: Neuroimage Clin Date: 2020-02-25 Impact factor: 4.881