Literature DB >> 24099014

Mechanisms of drug-induced liver injury.

Liyun Yuan1, Neil Kaplowitz.   

Abstract

Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Adaptive immunity; Cell death; HLA associations; Idiosyncratic drug-induced liver injury; Mitochondria; Oxidative stress; Reactive metabolites; Stress signaling

Mesh：

Year:  2013        PMID： 24099014      PMCID： PMC3793205          DOI： 10.1016/j.cld.2013.07.002

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN： 1089-3261            Impact factor:   6.126


  64 in total

Review 1.  Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.

Authors:  Kit I Tong; Akira Kobayashi; Fumiki Katsuoka; Masayuki Yamamoto
Journal:  Biol Chem       Date:  2006 Oct-Nov       Impact factor: 3.915

Review 2.  The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.

Authors:  Ian M Copple; Christopher E Goldring; Neil R Kitteringham; B Kevin Park
Journal:  Toxicology       Date:  2007-11-12       Impact factor: 4.221

Review 3.  The BCL-2 protein family: opposing activities that mediate cell death.

Authors:  Richard J Youle; Andreas Strasser
Journal:  Nat Rev Mol Cell Biol       Date:  2008-01       Impact factor: 94.444

Review 4.  Mitochondrial dynamics and apoptosis.

Authors:  Der-Fen Suen; Kristi L Norris; Richard J Youle
Journal:  Genes Dev       Date:  2008-06-15       Impact factor: 11.361

5.  Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.

Authors:  Kit I Tong; Balasundaram Padmanabhan; Akira Kobayashi; Chengwei Shang; Yosuke Hirotsu; Shigeyuki Yokoyama; Masayuki Yamamoto
Journal:  Mol Cell Biol       Date:  2007-09-04       Impact factor: 4.272

Review 6.  Drug-induced liver injury.

Authors:  Gebran Abboud; Neil Kaplowitz
Journal:  Drug Saf       Date:  2007       Impact factor: 5.606

7.  Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals.

Authors:  Craig Lammert; Stefan Einarsson; Chandan Saha; Anna Niklasson; Einar Bjornsson; Naga Chalasani
Journal:  Hepatology       Date:  2008-06       Impact factor: 17.425

8.  Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.

Authors:  Patrick J Shaw; Marie J Hopfensperger; Patricia E Ganey; Robert A Roth
Journal:  Toxicol Sci       Date:  2007-08-19       Impact factor: 4.849

9.  Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes.

Authors:  Behnam Saberi; Mie Shinohara; Maria D Ybanez; Naoko Hanawa; William A Gaarde; Neil Kaplowitz; Derick Han
Journal:  Am J Physiol Cell Physiol       Date:  2008-05-07       Impact factor: 4.249

10.  PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding.

Authors:  Michael Lazarou; Derek P Narendra; Seok Min Jin; Ephrem Tekle; Soojay Banerjee; Richard J Youle
Journal:  J Cell Biol       Date:  2013-01-14       Impact factor: 10.539
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  60 in total

Review 1.  Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy.

Authors:  Shannan R Tujios; William M Lee
Journal:  Liver Int       Date:  2017-09-18       Impact factor: 5.828

2.  Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration?

Authors:  Udayan Apte; Neil Kaplowitz
Journal:  Hepatology       Date:  2017-09-29       Impact factor: 17.425

3.  Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization.

Authors:  Dong Fu; Panli Cardona; Henry Ho; Paul B Watkins; Kim L R Brouwer
Journal:  Toxicol Sci       Date:  2019-07-31       Impact factor: 4.849

4.  Liver injury during rivaroxaban treatment in a patient with AL amyloidosis.

Authors:  Alan Marrinan; L Shackleton; C Kelly; M Lavin; S Glavey; P Murphy; J Quinn
Journal:  Eur J Clin Pharmacol       Date:  2021-01-11       Impact factor: 2.953

5.  Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

Authors:  Michal Pyzik; Timo Rath; Timothy T Kuo; Sanda Win; Kristi Baker; Jonathan J Hubbard; Rosa Grenha; Amit Gandhi; Thomas D Krämer; Adam R Mezo; Zachary S Taylor; Kevin McDonnell; Vicki Nienaber; Jan Terje Andersen; Atsushi Mizoguchi; Laurence Blumberg; Shalaka Purohit; Susan D Jones; Greg Christianson; Wayne I Lencer; Inger Sandlie; Neil Kaplowitz; Derry C Roopenian; Richard S Blumberg
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-22       Impact factor: 11.205

Review 6.  Pregnane X receptor and drug-induced liver injury.

Authors:  Yue-Ming Wang; Sergio C Chai; Christopher T Brewer; Taosheng Chen
Journal:  Expert Opin Drug Metab Toxicol       Date:  2014-09-25       Impact factor: 4.481

7.  Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.

Authors:  Jiekun Xuan; Si Chen; Baitang Ning; William H Tolleson; Lei Guo
Journal:  Chem Biol Interact       Date:  2015-10-22       Impact factor: 5.192

8.  Optimization of decision support tool using medication regimens to assess rehospitalization risks.

Authors:  C H Olson; M Dierich; T Adam; B L Westra
Journal:  Appl Clin Inform       Date:  2014-08-27       Impact factor: 2.342

9.  The Opportunities of Metabolomics in Drug Safety Evaluation.

Authors:  Pengcheng Wang; Amina I Shehu; Xiaochao Ma
Journal:  Curr Pharmacol Rep       Date:  2017-01-03

10.  Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline.

Authors:  Zhen Ren; Si Chen; Ji-Eun Seo; Xiaoqing Guo; Dongying Li; Baitang Ning; Lei Guo
Journal:  Toxicol In Vitro       Date:  2020-08-28       Impact factor: 3.500
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