Literature DB >> 24098966

Pd(II)-catalyzed ortho-trifluoromethylation of benzylamines.

Masanori Miura1, Chen-Guo Feng, Sandy Ma, Jin-Quan Yu.   

Abstract

The Pd(II)-catalyzed ortho-C-H trifluoromethylation of benzylamines has been achieved utilizing an electrophilic CF3 reagent. Additives, such as H2O and Ag2O, were found to be crucial for obtaining good yields. This protocol will be useful in medicinal chemistry for the preparation of ortho-trifluoromethyl-substituted benzylamines.

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Year:  2013        PMID： 24098966     DOI： 10.1021/ol402471y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  Ligand-Promoted meta-C-H Functionalization of Benzylamines.

Authors:  Peng Wang; Marcus E Farmer; Jin-Quan Yu
Journal:  Angew Chem Int Ed Engl       Date:  2017-03-30       Impact factor: 15.336

2.  Bond-Forming and -Breaking Reactions at Sulfur(IV): Sulfoxides, Sulfonium Salts, Sulfur Ylides, and Sulfinate Salts.

Authors:  Daniel Kaiser; Immo Klose; Rik Oost; James Neuhaus; Nuno Maulide
Journal:  Chem Rev       Date:  2019-06-25       Impact factor: 60.622

3.  Iron-Catalyzed Oxyfunctionalization of Aliphatic Amines at Remote Benzylic C-H Sites.

Authors:  Curren T Mbofana; Eugene Chong; James Lawniczak; Melanie S Sanford
Journal:  Org Lett       Date:  2016-08-16       Impact factor: 6.005

4.  Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons.

Authors:  Brian N Laforteza; Kelvin S L Chan; Jin-Quan Yu
Journal:  Angew Chem Int Ed Engl       Date:  2015-08-04       Impact factor: 15.336

5.  Ligand-Enabled meta-Selective C-H Arylation of Nosyl-Protected Phenethylamines, Benzylamines, and 2-Aryl Anilines.

Authors:  Qiuping Ding; Shengqing Ye; Guolin Cheng; Peng Wang; Marcus E Farmer; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2016-12-23       Impact factor: 15.419

6.  Rh(iii)-catalyzed C-H olefination of N-pentafluoroaryl benzamides using air as the sole oxidant.

Authors:  Yi Lu; Huai-Wei Wang; Jillian E Spangler; Kai Chen; Pei-Pei Cui; Yue Zhao; Wei-Yin Sun; Jin-Quan Yu
Journal:  Chem Sci       Date:  2015-01-08       Impact factor: 9.825

7.  The α-tertiary amine motif drives remarkable selectivity for Pd-catalyzed carbonylation of β-methylene C-H bonds.

Authors:  Kirsten F Hogg; Aaron Trowbridge; Andrea Alvarez-Pérez; Matthew J Gaunt
Journal:  Chem Sci       Date:  2017-10-09       Impact factor: 9.825

Review 8.  Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups.

Authors:  Xiaowei Li; Xiaolin Shi; Xiangqian Li; Dayong Shi
Journal:  Beilstein J Org Chem       Date:  2019-09-23       Impact factor: 2.883

9.  Crystal structure of 1-methyl-3-[2,2,2-tri-fluoro-1-(1-methyl-1H-indol-3-yl)-1-phenyl-eth-yl]-1H-indole.

Authors:  Xian-Rong Liu; Yan-Ling Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-11
  9 in total

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