Spontaneous loss of hypersensitivity in patients allergic to bee or wasp stings; detection by venom-induced histamine release.

Patients with bee or wasp sting allergy can lose their hypersensitivity spontaneously. The suitability of venom-induced histamine release for evaluating the actual allergic risk in untreated patients with a history of systemic allergic reactions following bee or wasp stings is demonstrated by successfully deliberate sting challenges.