Literature DB >> 2409759

Role of cyclic AMP in the induction of histamine secretion from mast cells.

A Leoutsakos, A Truneh, F L Pearce.   

Abstract

Immunological activation of rat peritoneal mast cells induced a transient elevation in the intracellular concentration of cyclic AMP. Enhancement or suppression of this rise by appropriate adenosine analogues produced parallel changes in histamine secretion. However, pharmacological activation of the cell with a number of diverse ligands induced histamine release without any accompanying changes in cyclic AMP. Moreover, this release was modulated by adenosine analogues in identical fashion to IGE-directed ligands but again without affecting cyclic AMP. On the basis of these results, the possible role of cyclic AMP in the induction of histamine secretion is critically considered.

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Year:  1985        PMID： 2409759     DOI： 10.1007/bf01983118

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

Review 1.  Physiological roles for adenosine and adenosine 5'-triphosphate in the nervous system.

Authors:  T W Stone
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

2.  Changes in cellular levels of cyclic AMP in rat mast cells during secretion of histamine induced by immunoglobulin E decapeptide and ACTH(1-24) peptide. Comparison with immunological and ionophore triggers.

Authors:  D S Burt; D R Stanworth
Journal:  Biochim Biophys Acta       Date:  1983-06-02

3.  Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs.

Authors:  S T Holgate; R A Lewis; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

Review 4.  Calcium and histamine secretion from mast cells.

Authors:  F L Pearce
Journal:  Prog Med Chem       Date:  1982

5.  Characteristics of histamine secretion from rat peritoneal mast cells sensitized to the nematode Nippostrongylus brasiliensis.

Authors:  J R White; F L Pearce
Journal:  Immunology       Date:  1982-06       Impact factor: 7.397

6.  Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines.

Authors:  P E Alm
Journal:  Agents Actions       Date:  1983-04
  6 in total
  5 in total

1.  Effects of antihistamines on isolated rat peritoneal mast cells and on model membrane systems.

Authors:  H Y Lau; F L Pearce
Journal:  Agents Actions       Date:  1990-03

2.  Some characteristics of histamine secretion from rat peritoneal mast cells stimulated with nerve growth factor.

Authors:  F L Pearce; H L Thompson
Journal:  J Physiol       Date:  1986-03       Impact factor: 5.182

3.  Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells.

Authors:  M K Church; P J Hughes; C J Vardey
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

4.  Dual actions of adenosine on rat peritoneal mast cells.

Authors:  M J Lohse; K Maurer; H P Gensheimer; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

5.  Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells.

Authors:  Z H Jaffar; F L Pearce
Journal:  Agents Actions       Date:  1993-09
  5 in total

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