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Literature DB >> 24096399

Substrate-induced rearrangements in glutamate-transporter homologs.

Abstract

Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.

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Year: 2013 PMID： 24096399 DOI： 10.1038/nsmb.2685

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

14 in total

1. Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph).

Authors: Maarten Groeneveld; Dirk-Jan Slotboom
Journal: Biochemistry Date: 2010-05-04 Impact factor: 3.162

2. Structure of a glutamate transporter homologue from Pyrococcus horikoshii.

Authors: Dinesh Yernool; Olga Boudker; Yan Jin; Eric Gouaux
Journal: Nature Date: 2004-10-14 Impact factor: 49.962

3. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.

Authors: Olga Boudker; Renae M Ryan; Dinesh Yernool; Keiko Shimamoto; Eric Gouaux
Journal: Nature Date: 2007-01-17 Impact factor: 49.962

4. Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii.

Authors: Renae M Ryan; Emma L R Compton; Joseph A Mindell
Journal: J Biol Chem Date: 2009-04-20 Impact factor: 5.157

5. Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis.

Authors: Lihi Brocke; Annie Bendahan; Myriam Grunewald; Baruch I Kanner
Journal: J Biol Chem Date: 2001-11-27 Impact factor: 5.157

6. Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter.

Authors: A Bendahan; A Armon; N Madani; M P Kavanaugh; B I Kanner
Journal: J Biol Chem Date: 2000-12-01 Impact factor: 5.157

7. Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter.

Authors: Y Zhang; A Bendahan; R Zarbiv; M P Kavanaugh; B I Kanner
Journal: Proc Natl Acad Sci U S A Date: 1998-01-20 Impact factor: 11.205

8. Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange.

Authors: M P Kavanaugh; A Bendahan; N Zerangue; Y Zhang; B I Kanner
Journal: J Biol Chem Date: 1997-01-17 Impact factor: 5.157