D Ondrus1, M Ondrusova, L Friedova. 1. 1st Department of Oncology, Faculty of Medicine, St. Elisabeth Cancer Institute, Comenius University, Heydukova 10, 812 50, Bratislava, Slovak Republic, dalibor.ondrus@ousa.sk.
Abstract
PURPOSE: The objective of the present study is to analyze long-term testicular cancer (TC) survivors focusing on the correlation of therapeutic modalities used, the age of patients and second malignancy (SM) occurrence. PATIENTS AND METHODS: A total of 1,367 patients with TC and different subsequent therapeutic procedures were followed up between 1970 and 2012. The occurrence of SM was analyzed by standard incidence ratios (SIR). SM occurred in 96 (7.0 %) patients with primary TC. RESULTS: The most frequent SM was TC (SIR 27.4, n = 64); a significantly higher occurrence was observed after primary testicular seminoma. Prostate cancer appeared in 10 patients (SIR 5.2), with a mean age 54.9 years, while the typical age of patients in Slovakia was 71.4 years. Kidney cancer developed in 6 patients, a significant higher SIR was registered only after primary non-seminomas. The mean patient's age was 48.5 years, while the typical age of all male patients in Slovakia was 62.4 years. Other SM had no significantly higher SIR. Colorectal cancer appeared in 8 patients with primary TC, with a mean age 56.0 years, while the typical age of male patients with primary colorectal cancer in Slovakia was 67.1 years. Other non-testicular tumors appeared in 8 patients. SM occurs in 1.5 % of patients following orchiectomy alone, in 4.3 % following radiotherapy, 5.0 % following chemotherapy and in 4.4 % following combined chemo-radiotherapy. CONCLUSIONS: Preliminary analyses indicate increased SM occurrence in patients with primary TC in comparison with the general population, and it also occurs in younger age at the time of SM diagnosis.
PURPOSE: The objective of the present study is to analyze long-term testicular cancer (TC) survivors focusing on the correlation of therapeutic modalities used, the age of patients and second malignancy (SM) occurrence. PATIENTS AND METHODS: A total of 1,367 patients with TC and different subsequent therapeutic procedures were followed up between 1970 and 2012. The occurrence of SM was analyzed by standard incidence ratios (SIR). SM occurred in 96 (7.0 %) patients with primary TC. RESULTS: The most frequent SM was TC (SIR 27.4, n = 64); a significantly higher occurrence was observed after primary testicular seminoma. Prostate cancer appeared in 10 patients (SIR 5.2), with a mean age 54.9 years, while the typical age of patients in Slovakia was 71.4 years. Kidney cancer developed in 6 patients, a significant higher SIR was registered only after primary non-seminomas. The mean patient's age was 48.5 years, while the typical age of all male patients in Slovakia was 62.4 years. Other SM had no significantly higher SIR. Colorectal cancer appeared in 8 patients with primary TC, with a mean age 56.0 years, while the typical age of male patients with primary colorectal cancer in Slovakia was 67.1 years. Other non-testicular tumors appeared in 8 patients. SM occurs in 1.5 % of patients following orchiectomy alone, in 4.3 % following radiotherapy, 5.0 % following chemotherapy and in 4.4 % following combined chemo-radiotherapy. CONCLUSIONS: Preliminary analyses indicate increased SM occurrence in patients with primary TC in comparison with the general population, and it also occurs in younger age at the time of SM diagnosis.
Authors: Tomas Buchler; Petra Kubankova; Ludmila Boublikova; Zuzana Donatova; Martin Foldyna; Jana Kanakova; Drahomira Kordikova; Martin Kupec; Jana Nepomucka; Eva Vorsilkova; Jitka Abrahamova Journal: Cancer Date: 2011-04-08 Impact factor: 6.860
Authors: Lorenzo Richiardi; Ghislaine Scélo; Paolo Boffetta; Kari Hemminki; Eero Pukkala; Jorgen H Olsen; Elisabete Weiderpass; Elizabeth Tracey; David H Brewster; Mary L McBride; Erich V Kliewer; Jon M Tonita; Vera Pompe-Kirn; Chia Kee-Seng; Jon G Jonasson; Carmen Martos; Paul Brennan Journal: Int J Cancer Date: 2007-02-01 Impact factor: 7.396
Authors: Hege S Haugnes; George J Bosl; Hink Boer; Jourik A Gietema; Marianne Brydøy; Jan Oldenburg; Alv A Dahl; Roy M Bremnes; Sophie D Fosså Journal: J Clin Oncol Date: 2012-09-24 Impact factor: 44.544
Authors: Catherine Schairer; Michie Hisada; Bingshu E Chen; Linda M Brown; Regan Howard; Sophie D Fosså; Mitchell Gail; Lois B Travis Journal: J Natl Cancer Inst Date: 2007-08-08 Impact factor: 13.506
Authors: Berbel L M Ykema; Emilie C H Breekveldt; Beatriz Carvalho; Tom van Wezel; Gerrit A Meijer; Martijn Kerst; Michael Schaapveld; Flora E van Leeuwen; Petur Snaebjornsson; Monique E van Leerdam Journal: Br J Cancer Date: 2022-09-10 Impact factor: 9.075
Authors: Jennifer A Soon; Angelyn Anton; Javier Torres; Ruth Lawrence; Phillip Parente; Joseph McKendrick; Ian D Davis; Carmel Pezaro Journal: Support Care Cancer Date: 2018-10-22 Impact factor: 3.603
Authors: Berbel L M Ykema; Tanya M Bisseling; Manon C W Spaander; Leon M G Moons; Dorien van der Biessen-van Beek; Lisette Saveur; Martijn Kerst; Sasja F Mulder; Ronald de Wit; Danielle Zweers; Gerrit A Meijer; Jos H Beijnen; Iris Lansdorp-Vogelaar; Flora E van Leeuwen; Petur Snaebjornsson; Monique E van Leerdam Journal: BMC Gastroenterol Date: 2021-02-12 Impact factor: 3.067