| Literature DB >> 24095826 |
Eser J Zerenturk1, Laura J Sharpe, Elina Ikonen, Andrew J Brown.
Abstract
3β-Hydroxysterol Δ(24)-reductase (DHCR24) catalyzes the conversion of desmosterol to cholesterol. This ultimate step of cholesterol biosynthesis appears to be remarkable in its diverse functions and the number of diseases it is implicated in from vascular disease to Hepatitis C virus (HCV) infection to cancer to Alzheimer's disease. This review summarizes the present knowledge on the DHCR24 gene, sterol Δ(24)-reductase protein and the regulation of both. In addition, the functions of desmosterol, DHCR24 and their roles in human diseases are discussed. It is apparent that DHCR24 exerts more complex effects than what would be expected based on the enzymatic activity of sterol Δ(24)-reduction alone, such as its influence in modulating oxidative stress. Increasing information about DHCR24 membrane association, processing, enzymatic regulation and interaction partners will provide further fundamental insights into DHCR24 and its many and varied biological roles.Entities:
Keywords: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3β-Hydroxysterol Δ(24)-reductase; 3β-hydroxysterol Δ(24)-reductase; 7-dehydrocholesterol reductase; ACTH; Bloch pathway; CAR; Cholesterol; Cholesterol homeostasis; DHCR24; DHCR7; DWF1; Desmosterol; Desmosterolosis; ER; FAD; HCV; HDL; HMGCR; LXR; Mdm2; NF-Y; PXR; SRE; SREBP; SREBP-cleavage activating protein; Scap; Seladin-1; Sp1; TH; adrenocorticotropic hormone; constitutive androstane receptor; dwarf 1; endoplasmic reticulum; flavin adenine dinucleotide; hepatitis C virus; high-density lipoprotein; liver X receptor; mouse double minute 2 homolog; nuclear factor Y; pregnane X receptor; selective Alzheimer’s disease indicator-1; specificity protein 1; sterol regulatory element; sterol regulatory element binding protein; thyroid hormone
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Year: 2013 PMID： 24095826 DOI： 10.1016/j.plipres.2013.09.002
Source DB: PubMed Journal: Prog Lipid Res ISSN： 0163-7827 Impact factor: 16.195