Aikebaier Wumaner1, Aziguli Keremu2, Dilixiati Wumaier3, Qing Wang4. 1. Xinjiang Clinic College, Anhui Medical University, No. 84 Meishan Road, Chushan Area, Hefei 200135, China. 2. Department of Clinical Laboratory, People's Hospital of Xinjiang Uyghur Autonomous Region, No. 91 Tianchi Roud, Tianshan Area, Urumqi 830001, Xinjiang, China. 3. Department of Urology, First People's Hospital of Kashi, No. 66 Yingbin Road, Kashi 844000, Xinjiang, China. 4. Xinjiang Clinic College, Anhui Medical University, No. 84 Meishan Road, Chushan Area, Hefei 200135, China. Electronic address: wangqing1570@126.com.
Abstract
OBJECTIVE: To analyze the causes of urolithiasis in Uyghur children from Xinjiang. PATIENTS AND METHODS: We retrospectively evaluated the clinical features and characteristics of urinary stone composition of 220 Uyghur pediatric patients with urolithiasis between March 2009 and June 2011. The data were compared with that of 100 Uyghur children without urolithiasis who visited the Child Care Clinic for regular health check-ups. The stones were collected by endoscopy or open surgery, and analyzed using infrared spectroscopy. RESULTS: The mean age of the 220 Uyghur children was 7.48 ± 4.73 years (range, 0.8-17.0 years). The overall sex ratio (male:female) was 2.23:1. The predominant pure stone was ammonium urate (58.9%), whereas the predominant mixed stone was calcium oxalate mixture (91.1%). Uric acid stones comprised 54% of all stones. Urinary tract infections were observed in 42.3% and 4.0% of the patient and control groups, respectively. The mean urinary pH values were 5.77 ± 0.67 and 6.42 ± 0.67, respectively (p < 0.001). pH values were <5.5 in 52.7% and 6% of the patient and control groups, respectively. On 24-h urine analysis, we found metabolic disturbances in these patients: hypercalciuria in 6.8% cases, hyperphosphaturia in 16.8% cases, hyperuricosuria in 21.4% cases, and hypomagnesiuria in 34.1% cases. CONCLUSIONS: Urolithiasis in Uyghur children may be primarily related to local environmental factors.
OBJECTIVE: To analyze the causes of urolithiasis in Uyghur children from Xinjiang. PATIENTS AND METHODS: We retrospectively evaluated the clinical features and characteristics of urinary stone composition of 220 Uyghur pediatric patients with urolithiasis between March 2009 and June 2011. The data were compared with that of 100 Uyghur children without urolithiasis who visited the Child Care Clinic for regular health check-ups. The stones were collected by endoscopy or open surgery, and analyzed using infrared spectroscopy. RESULTS: The mean age of the 220 Uyghur children was 7.48 ± 4.73 years (range, 0.8-17.0 years). The overall sex ratio (male:female) was 2.23:1. The predominant pure stone was ammonium urate (58.9%), whereas the predominant mixed stone was calcium oxalate mixture (91.1%). Uric acid stones comprised 54% of all stones. Urinary tract infections were observed in 42.3% and 4.0% of the patient and control groups, respectively. The mean urinary pH values were 5.77 ± 0.67 and 6.42 ± 0.67, respectively (p < 0.001). pH values were <5.5 in 52.7% and 6% of the patient and control groups, respectively. On 24-h urine analysis, we found metabolic disturbances in these patients: hypercalciuria in 6.8% cases, hyperphosphaturia in 16.8% cases, hyperuricosuria in 21.4% cases, and hypomagnesiuria in 34.1% cases. CONCLUSIONS:Urolithiasis in Uyghur children may be primarily related to local environmental factors.
Authors: Rohana Chandrajith; Anushka Weerasingha; Kusala M Premaratne; Dhanushke Gamage; Anuruddha M Abeygunasekera; Michael M Joachimski; Atula Senaratne Journal: Environ Geochem Health Date: 2019-01-22 Impact factor: 4.609
Authors: Maria Goretti Moreira Guimarães Penido; Marcelo de Sousa Tavares; Milena Maria Moreira Guimarães; Tarak Srivastava; Uri Saggie Alon Journal: Glob Pediatr Health Date: 2014-11-28