| Literature DB >> 24095664 |
Rishikesh Shukla1, Arun Goyal.
Abstract
The porous branched dextran of molecular mass 2.93 × 10(5) Da with 50% overall yield (4.5mg/ml) was produced from Pediococcus pentosaceus CRAG3 (GenBank ID: JX679020), a novel isolate from fermented cucumber. It contained glucose monomers linked through 75% α-(1,6) linkage with 25% (α-1,3) branching as displayed by spectroscopic analysis. The peak analysis showed α-(1,3) branching after every five glucose units of main chain. In vitro cytotoxicity analysis of dextran displayed anti-cancer activity against cervical cancer (HeLa) and colon cancer (HT29) cell lines opening new horizons in its pharmaceutical applications. Dextran showed enhanced growth of macrophage lines revealing its biocompatible nature.Entities:
Keywords: Anti-cancer; Dextran; NMR; Pediococcus pentosaceus; SEM
Mesh：
Substances：
Year: 2013 PMID： 24095664 DOI： 10.1016/j.ijbiomac.2013.09.043
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953