Chiara Sileo1, Harriet Corvol2, Pierre-Yves Boelle3, Eléonore Blondiaux1, Annick Clement4, Hubert Ducou Le Pointe1. 1. AP-HP, Hôpital Trousseau, Pediatric Radiology Department, Paris, France; Université Pierre et Marie Curie - Paris 6, Paris, France. 2. Université Pierre et Marie Curie - Paris 6, Paris, France; AP-HP, Hôpital Trousseau, Paediatric Pulmonary Department, INSERM U938, Paris, France. Electronic address: harriet.corvol@trs.aphp.fr. 3. Université Pierre et Marie Curie - Paris 6, Paris, France; AP-HP, Hôpital St Antoine, Biostatistics Department, INSERM U707, Paris, France. 4. Université Pierre et Marie Curie - Paris 6, Paris, France; AP-HP, Hôpital Trousseau, Paediatric Pulmonary Department, INSERM U938, Paris, France.
Abstract
BACKGROUND: Chest imaging is essential in the assessment of respiratory disease in cystic fibrosis (CF). High-resolution computed tomography (HRCT) can detect progressive lung disease but involves significant delivered dose of ionizing radiation. Magnetic resonance imaging (MRI) is radiation-free but is rarely used in CF. Based on the limited information on the potential interest of chest MRI in CF pediatric patients, the aims of our study were: 1) to evaluate and compare the reproducibility of HRCT and MRI scores; and 2) to evaluate the agreement between HRCT and MRI scores using both Helbich and Eichinger scores. METHODS: In this prospective study, CF children who were having a HRCT for their routine assessment were proposed to perform a chest MRI the same day. 17 patients were included (median age 12.7 years). Two radiologists scored independently HRCT (Helbich score) and MRI (Helbich and Eichinger scores); and established a consensus score. Concordance was assessed using the Intraclass Correlation Coefficient (ICC); and the inter-observer reproducibility between methods was compared using Fisher's Z test for dependent observations. RESULTS: Concordance between readers was almost perfect for HRCT score (ICC = 96%) and MRI-Eichinger score (84%), and substantial for MRI-Helbich score (68%). Correlation was strong between HRCT and MRI (r = 0.86 and 0.91 for HRCT and respectively MRI-Eichinger and MRI-Helbich scores) and the concordance almost perfect and substantial (ICC = 86% and 78% for HRCT and respectively MRI-Eichinger and MRI-Helbich scores). CONCLUSIONS: We showed that, in CF children, MRI could adequately visualize lung morphologic changes when compared with the "gold-standard" HRCT. Regarding the potential cancer risks from associated ionizing radiation with HRCT, these results lead us to propose larger intervals of time between two lung HRCTs with realization of lung MRI in the meantime.
BACKGROUND: Chest imaging is essential in the assessment of respiratory disease in cystic fibrosis (CF). High-resolution computed tomography (HRCT) can detect progressive lung disease but involves significant delivered dose of ionizing radiation. Magnetic resonance imaging (MRI) is radiation-free but is rarely used in CF. Based on the limited information on the potential interest of chest MRI in CF pediatric patients, the aims of our study were: 1) to evaluate and compare the reproducibility of HRCT and MRI scores; and 2) to evaluate the agreement between HRCT and MRI scores using both Helbich and Eichinger scores. METHODS: In this prospective study, CF children who were having a HRCT for their routine assessment were proposed to perform a chest MRI the same day. 17 patients were included (median age 12.7 years). Two radiologists scored independently HRCT (Helbich score) and MRI (Helbich and Eichinger scores); and established a consensus score. Concordance was assessed using the Intraclass Correlation Coefficient (ICC); and the inter-observer reproducibility between methods was compared using Fisher's Z test for dependent observations. RESULTS: Concordance between readers was almost perfect for HRCT score (ICC = 96%) and MRI-Eichinger score (84%), and substantial for MRI-Helbich score (68%). Correlation was strong between HRCT and MRI (r = 0.86 and 0.91 for HRCT and respectively MRI-Eichinger and MRI-Helbich scores) and the concordance almost perfect and substantial (ICC = 86% and 78% for HRCT and respectively MRI-Eichinger and MRI-Helbich scores). CONCLUSIONS: We showed that, in CF children, MRI could adequately visualize lung morphologic changes when compared with the "gold-standard" HRCT. Regarding the potential cancer risks from associated ionizing radiation with HRCT, these results lead us to propose larger intervals of time between two lung HRCTs with realization of lung MRI in the meantime.
Authors: Jason C Woods; Jim M Wild; Mark O Wielpütz; John P Clancy; Hiroto Hatabu; Hans-Ulrich Kauczor; Edwin J R van Beek; Talissa A Altes Journal: J Magn Reson Imaging Date: 2019-12-17 Impact factor: 4.813
Authors: Rodrigo Abensur Athanazio; Luiz Vicente Ribeiro Ferreira da Silva Filho; Alberto Andrade Vergara; Antônio Fernando Ribeiro; Carlos Antônio Riedi; Elenara da Fonseca Andrade Procianoy; Fabíola Villac Adde; Francisco José Caldeira Reis; José Dirceu Ribeiro; Lídia Alice Torres; Marcelo Bicalho de Fuccio; Matias Epifanio; Mônica de Cássia Firmida; Neiva Damaceno; Norberto Ludwig-Neto; Paulo José Cauduro Maróstica; Samia Zahi Rached; Suzana Fonseca de Oliveira Melo Journal: J Bras Pneumol Date: 2017 May-Jun Impact factor: 2.624