Literature DB >> 24095157

Glycaemic instability correlates with a hyperglucagonaemic response in patients with type 1 diabetes without residual beta-cell function.

Megumi Bessho1, Yuko Murase-Mishiba, Chiharu Tsutsumi, Fumitaka Haseda, Akihisa Imagawa, Jungo Terasaki, Toshiaki Hanafusa.   

Abstract

We investigated the association between arginine-stimulated glucagon secretion (AUCIRG) and several parameters of glycaemic variability in 12 patients with type 1 diabetes without residual beta-cell function. AUCIRG positively correlated with the SD and mean amplitude of glycaemic excursions, thus glucagon might contribute to glycaemic instability, independent of endogenous insulin.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Glucagon; Glycaemic instability; Type 1 diabetes

Mesh：

Substances：

Year:  2013        PMID： 24095157     DOI： 10.1016/j.diabres.2013.09.003

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  6 in total

1.  Case of aniridia with a heterozygous PAX6 mutation in which the glucagon response to arginine was evaluated.

Authors:  Saeko Osawa; Tetsuyuki Yasuda; Hideaki Kaneto; Naoki Shimo; Yuichi Yamamoto; Dan Kawamori; Takeshi Miyatsuka; Taka-Aki Matsuoka; Iichiro Shimomura
Journal:  J Diabetes Investig       Date:  2015-01-01       Impact factor: 4.232

2.  Possible contribution of taurine to distorted glucagon secretion in intra-islet insulin deficiency: a metabolome analysis using a novel α-cell model of insulin-deficient diabetes.

Authors:  Megumi Bessho; Yuko Murase-Mishiba; Akihisa Imagawa; Jungo Terasaki; Toshiaki Hanafusa
Journal:  PLoS One       Date:  2014-11-13       Impact factor: 3.240

3.  "Preserved" glucagon secretion in fulminant type 1 diabetes.

Authors:  Yuko Murase-Mishiba; Megumi Bessho-Tachibana; Akihisa Imagawa
Journal:  J Diabetes Investig       Date:  2018-11-09       Impact factor: 4.232

Review 4.  The Role of Glucagon in Glycemic Variability in Type 1 Diabetes: A Narrative Review.

Authors:  Keyu Guo; Qi Tian; Lin Yang; Zhiguang Zhou
Journal:  Diabetes Metab Syndr Obes       Date:  2021-12-21       Impact factor: 3.168

5.  Contribution of pancreatic α-cell function to insulin sensitivity and glycemic variability in patients with type 1 diabetes.

Authors:  Nobuyuki Takahashi; Daisuke Chujo; Hiroshi Kajio; Kohjiro Ueki
Journal:  J Diabetes Investig       Date:  2018-10-30       Impact factor: 4.232

6.  Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients.

Authors:  Minyoung Lee; Minkyung Kim; Jong Suk Park; Sangbae Lee; Jihong You; Chul Woo Ahn; Kyung Rae Kim; Shinae Kang
Journal:  Korean J Intern Med       Date:  2017-09-08       Impact factor: 2.884
  6 in total

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