| Literature DB >> 24095129 |
Gregor K Wenning1, Florian Krismer.
Abstract
Multiple system atrophy (MSA) is a sporadic and fatal α-synuclein-linked oligodendrogliopathy manifesting with progressive autonomic failure, poorly levodopa-responsive parkinsonism, and cerebellar ataxia, in any combination. Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, and translational therapies aimed at disease modification.Entities:
Keywords: Multiple system atrophy; autonomic failure; cerebellar ataxia; orthostatic hypotension; parkinsonism; therapy; urogenital failure
Mesh：
Year: 2013 PMID： 24095129 DOI： 10.1016/B978-0-444-53491-0.00019-5
Source DB: PubMed Journal: Handb Clin Neurol ISSN： 0072-9752