AIM: We aimed to define the etiologic and prognostic factors in live-born infants with hydrops fetalis (HF) in our tertiary neonatal intensive care unit over a 10-year period. METHODS: Medical records of newborn infants with HF during 2002-2011 were reviewed retrospectively. Demographic data, prenatal interventions, clinical and laboratory findings, outcomes, and the results of postmortem examinations were analyzed. RESULTS: During the study period, 62 newborn infants with HF were identified from 16,200 live-born deliveries and the incidence of HF was 3.8/1000 live births in our hospital. Twenty-eight infants (45.2%) had immune HF, whereas 34 (54.8%) had nonimmune HF. An etiologic factor could be identified in 24 (70.5%) infants with nonimmune HF. Lymphatic dysplasias comprised the majority (23.5%) of the infants with nonimmune HF. Mortality rate was 50%. The presence of two or more serous cavity effusions and gestational age were independently associated with the risk of mortality. CONCLUSION: Despite the improvements in neonatal care, mortality rate in infants with HF is still high. Gestational age and the extent of serous cavity determine the risk of mortality. Timely and advanced prenatal or postnatal new therapeutic strategies may alter this fatal outcome in appropriate patients.
AIM: We aimed to define the etiologic and prognostic factors in live-born infants with hydrops fetalis (HF) in our tertiary neonatal intensive care unit over a 10-year period. METHODS: Medical records of newborn infants with HF during 2002-2011 were reviewed retrospectively. Demographic data, prenatal interventions, clinical and laboratory findings, outcomes, and the results of postmortem examinations were analyzed. RESULTS: During the study period, 62 newborn infants with HF were identified from 16,200 live-born deliveries and the incidence of HF was 3.8/1000 live births in our hospital. Twenty-eight infants (45.2%) had immune HF, whereas 34 (54.8%) had nonimmune HF. An etiologic factor could be identified in 24 (70.5%) infants with nonimmune HF. Lymphatic dysplasias comprised the majority (23.5%) of the infants with nonimmune HF. Mortality rate was 50%. The presence of two or more serous cavity effusions and gestational age were independently associated with the risk of mortality. CONCLUSION: Despite the improvements in neonatal care, mortality rate in infants with HF is still high. Gestational age and the extent of serous cavity determine the risk of mortality. Timely and advanced prenatal or postnatal new therapeutic strategies may alter this fatal outcome in appropriate patients.
Authors: S Christopher Derderian; Cerine Jeanty; Shannon R Fleck; Lily S Cheng; Shabnam Peyvandi; Anita J Moon-Grady; Jody Farrell; Shinjiro Hirose; Juan Gonzalez; Roberta L Keller; Tippi C MacKenzie Journal: J Pediatr Surg Date: 2014-10-29 Impact factor: 2.545
Authors: Teresa N Sparks; Kao Thao; Billie R Lianoglou; Nina M Boe; Kari G Bruce; Ilina Datkhaeva; Nancy T Field; Victoria M Fratto; Jennifer Jolley; Louise C Laurent; Anne H Mardy; Aisling M Murphy; Emily Ngan; Naseem Rangwala; Catherine A M Rottkamp; Lisa Wilson; Erica Wu; Cherry C Uy; Priscila Valdez Lopez; Mary E Norton Journal: Genet Med Date: 2018-11-09 Impact factor: 8.822
Authors: Lars Schlotawa; Thomas Dierks; Sophie Christoph; Eva Cloppenburg; Andreas Ohlenbusch; G Christoph Korenke; Jutta Gärtner Journal: JIMD Rep Date: 2019-08-20