Andrea C King1, Patrick J McNamara2, Deborah S Hasin3, Dingcai Cao4. 1. Department of Psychiatry and Behavioral Neuroscience (ACK, PJM), University of Chicago, Chicago Illinois. Electronic address: aking@bsd.uchicago.edu. 2. Department of Psychiatry and Behavioral Neuroscience (ACK, PJM), University of Chicago, Chicago Illinois. 3. Columbia University College of Physicians and Surgeons (DH); Department of Psychiatry (DH), Mailman School of Public Health, Department of Epidemiology, New York, New York. 4. Department of Ophthalmology and Visual Sciences (DC), University of Illinois at Chicago, Chicago, Illinois.
Abstract
BACKGROUND: Propensity for alcohol misuse may be linked to an individuals' response to alcohol. This study examined the role of alcohol response phenotypes to future drinking problems. METHODS:One hundred four young heavy social drinkers participated in a within-subject, double-blind, placebo-controlled laboratory alcohol challenge study with 6-year follow-up. Participants were examined for subjective responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beverage, given in random order. Follow-up was conducted in 5 waves over 6 years after the sessions to assess drinking behaviors and alcohol use disorder (AUD) symptoms. Retention was high with 98% (509 of 520) of possible follow-ups completed. RESULTS: Greater sensitivity to alcohol, in terms of stimulation and rewarding effects (like, want more) and lower sensitivity to alcohol sedation predicted greater number of AUD symptoms through 6 years of follow-up. Cluster analyses revealed that for half the sample, increasing levels of stimulation and liking were predictors of more AUD symptoms with the other half divided between those showing like and want more and want more alone as significant predictors. CONCLUSIONS: The findings extend previous findings and offer new empirical insights into the propensity for excessive drinking and alcohol problems. Heightened alcohol stimulation and reward sensitivity robustly predicted more alcohol use disorder symptoms over time associated with greater binge-drinking frequency. These drinking problems were maintained and progressed as these participants were entering their third decade of life, a developmental interval when continued alcohol misuse becomes more deviant.
RCT Entities:
BACKGROUND: Propensity for alcohol misuse may be linked to an individuals' response to alcohol. This study examined the role of alcohol response phenotypes to future drinking problems. METHODS: One hundred four young heavy social drinkers participated in a within-subject, double-blind, placebo-controlled laboratory alcohol challenge study with 6-year follow-up. Participants were examined for subjective responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beverage, given in random order. Follow-up was conducted in 5 waves over 6 years after the sessions to assess drinking behaviors and alcohol use disorder (AUD) symptoms. Retention was high with 98% (509 of 520) of possible follow-ups completed. RESULTS: Greater sensitivity to alcohol, in terms of stimulation and rewarding effects (like, want more) and lower sensitivity to alcohol sedation predicted greater number of AUD symptoms through 6 years of follow-up. Cluster analyses revealed that for half the sample, increasing levels of stimulation and liking were predictors of more AUD symptoms with the other half divided between those showing like and want more and want more alone as significant predictors. CONCLUSIONS: The findings extend previous findings and offer new empirical insights into the propensity for excessive drinking and alcohol problems. Heightened alcohol stimulation and reward sensitivity robustly predicted more alcohol use disorder symptoms over time associated with greater binge-drinking frequency. These drinking problems were maintained and progressed as these participants were entering their third decade of life, a developmental interval when continued alcohol misuse becomes more deviant.
Authors: Suchitra Krishnan-Sarin; Stephanie S O'Malley; Nicholas Franco; Dana A Cavallo; Meghan Morean; Julia Shi; Brian Pittman; John H Krystal Journal: Alcohol Clin Exp Res Date: 2015-02-09 Impact factor: 3.455
Authors: Marc A Schuckit; Tom L Smith; Brinda K Rana; Lee Ann Mendoza; Dennis Clarke; Mari Kawamura Journal: Alcohol Clin Exp Res Date: 2019-05-02 Impact factor: 3.455
Authors: Jorge S Martins; Bruce D Bartholow; M Lynne Cooper; Kelsey M Irvin; Thomas M Piasecki Journal: Alcohol Clin Exp Res Date: 2019-07-18 Impact factor: 3.455
Authors: Benjamin L Berey; Robert F Leeman; Brian Pittman; Nicholas Franco; Suchitra Krishnan-Sarin Journal: Alcohol Alcohol Date: 2019-03-01 Impact factor: 2.826