Gabriel Horta-Baas1, Omar Guerrero-Soto, Leonor Barile-Fabris. 1. Servicio de Reumatología, Hospital General Regional 220, Instituto Mexicano del Seguro Social, Toluca de Lerdo, Estado de México, México. Electronic address: gabho@hotmail.com.
Abstract
INTRODUCTION: Infections in patients with systemic lupus erythematosus cause significant morbidity. Infection due to Listeria monocytogenes (LM) is considered an opportunistic disease, and has been published on rare occasions in patients with SLE. OBJECTIVE: To review the presentation of listeria infections in the central nervous system (CNS) in SLE patients. METHODOLOGY: We conducted a literature review, selecting cases with central nervous system infection and confirmation of LM infection through culture. RESULTS: Twenty six cases are described. The most common presentation was meningitis, with meningoencephalitis and brain abscesses being less frequent. The predisposing factors are: use of glucocorticoids, immunosuppressants, renal replacement therapy and the activity flares. CONCLUSION: CNS infection by listeria is rare and sometimes fatal. The atypical presentation may lead to a delay in diagnosis and appropriate treatment. L. monocytogenes should be included in the differential diagnosis of patients with SLE with neurological manifestations.
INTRODUCTION: Infections in patients with systemic lupus erythematosus cause significant morbidity. Infection due to Listeria monocytogenes (LM) is considered an opportunistic disease, and has been published on rare occasions in patients with SLE. OBJECTIVE: To review the presentation of listeria infections in the central nervous system (CNS) in SLEpatients. METHODOLOGY: We conducted a literature review, selecting cases with central nervous system infection and confirmation of LMinfection through culture. RESULTS: Twenty six cases are described. The most common presentation was meningitis, with meningoencephalitis and brain abscesses being less frequent. The predisposing factors are: use of glucocorticoids, immunosuppressants, renal replacement therapy and the activity flares. CONCLUSION: CNS infection by listeria is rare and sometimes fatal. The atypical presentation may lead to a delay in diagnosis and appropriate treatment. L. monocytogenes should be included in the differential diagnosis of patients with SLE with neurological manifestations.
Authors: Kiril E B van Veen; Matthijs C Brouwer; Arie van der Ende; Diederik van de Beek Journal: J Neuroimmune Pharmacol Date: 2016-09-09 Impact factor: 4.147