Using neuroimaging to inform clinical practice for the diagnosis and treatment of mild cognitive impairment.

Advances in structural and functional neuroimaging techniques have unquestionably improved understanding of the development and progression of Alzheimer disease (AD), with evidence supporting regional (and network) change that underlies cognitive decline across the "healthy" aging/mild cognitive impairment (MCI)/AD spectrum. This review focuses on visual rating scales and volumetric analyses that could be easily integrated into clinical practice, followed by a review of functional neuroimaging findings suggesting that widespread cerebral dysfunction underlies the learning and memory deficits in MCI. Evidence of preserved neuroplasticity in this population and that cognitive rehabilitation techniques may capitalize on this plasticity to improve cognition in those with MCI is also discussed. Published by Elsevier Inc.