Literature DB >> 24093673

Hereditary mtDNA heteroplasmy: a baseline for aging?

Michael Keogh1, Patrick F Chinnery.   

Abstract

Do mtDNA mutations contribute to the aging process, or are they innocent bystanders? Ross et al. (2013) show that inherited mtDNA point mutations lead to a premature aging phenotype in mice and "prime" the maternal lineage, interacting with subsequent somatic mutations to cause brain malformations and shorten lifespan.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24093673     DOI： 10.1016/j.cmet.2013.09.015

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  15 in total

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