BACKGROUND: Streptococcus pneumoniae causes a substantial proportion of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP) in the United States. Limited data are available regarding the pneumococcal serotypes causing CAP and HCAP. METHODS: Adults aged ≥ 50 years presenting to participating US hospitals with radiographically confirmed pneumonia between February 2010 and September 2011 were screened for inclusion. S. pneumoniae was identified using microbiological cultures, BinaxNOW® S. pneumoniae assay, or urine antigen detection (UAD) assay capable of detecting 13-valent pneumococcal conjugate vaccine (PCV13)-associated serotypes. RESULTS: Among 710 subjects enrolled, the median age was 65.4 years; 54.2% of subjects were male, 22.4% of radiographically confirmed pneumonia cases were considered HCAP, and 96.6% of subjects were hospitalized. S. pneumoniae was detected in 98 subjects (13.8%) by any test, and PCV13-associated serotype(s) were identified by UAD in 78 (11.0%). Serotype 19A was most prevalent, followed by 7F/A, 3, and 5. Serotypes associated with 7-valent pneumococcal conjugate vaccine (PCV7) accounted for 25% of UAD-positive isolates. CONCLUSIONS: Pneumococcal serotypes causing noninvasive pneumonia in adults may differ significantly from those causing invasive disease, with PCV7-associated serotypes overrepresented. Serotype 5, rarely seen in contemporary surveillance of invasive disease in the United States, substantially contributed to the observed cases of S. pneumoniae-positive CAP or HCAP.
BACKGROUND:Streptococcus pneumoniae causes a substantial proportion of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP) in the United States. Limited data are available regarding the pneumococcal serotypes causing CAP and HCAP. METHODS: Adults aged ≥ 50 years presenting to participating US hospitals with radiographically confirmed pneumonia between February 2010 and September 2011 were screened for inclusion. S. pneumoniae was identified using microbiological cultures, BinaxNOW® S. pneumoniae assay, or urine antigen detection (UAD) assay capable of detecting 13-valent pneumococcal conjugate vaccine (PCV13)-associated serotypes. RESULTS: Among 710 subjects enrolled, the median age was 65.4 years; 54.2% of subjects were male, 22.4% of radiographically confirmed pneumonia cases were considered HCAP, and 96.6% of subjects were hospitalized. S. pneumoniae was detected in 98 subjects (13.8%) by any test, and PCV13-associated serotype(s) were identified by UAD in 78 (11.0%). Serotype 19A was most prevalent, followed by 7F/A, 3, and 5. Serotypes associated with 7-valent pneumococcal conjugate vaccine (PCV7) accounted for 25% of UAD-positive isolates. CONCLUSIONS:Pneumococcal serotypes causing noninvasive pneumonia in adults may differ significantly from those causing invasive disease, with PCV7-associated serotypes overrepresented. Serotype 5, rarely seen in contemporary surveillance of invasive disease in the United States, substantially contributed to the observed cases of S. pneumoniae-positive CAP or HCAP.
Authors: Sun Jin Kim; Yoo Jung Jeong; Jong Hun Kim; Young Kyung Yoon; Jang Wook Sohn; Moon Hee Nahm; Min Ja Kim Journal: J Clin Microbiol Date: 2019-09-24 Impact factor: 5.948
Authors: Richard G Wunderink; Wesley H Self; Evan J Anderson; Robert Balk; Sherene Fakhran; Daniel Mark Courtney; Chao Qi; Derek J Williams; Yuwei Zhu; Cynthia G Whitney; Matthew R Moore; Anna Bramley; Seema Jain; Kathryn M Edwards; Carlos G Grijalva Journal: Clin Infect Dis Date: 2018-05-02 Impact factor: 9.079
Authors: Rodrigo E Mendes; Rosalind C Hollingsworth; Andrew Costello; Ronald N Jones; Raul E Isturiz; Dial Hewlett; David J Farrell Journal: Antimicrob Agents Chemother Date: 2015-06-29 Impact factor: 5.191
Authors: S P van Mens; A M M van Deursen; S C de Greeff; H E de Melker; L M Schouls; A van der Ende; M J M Bonten; E A M Sanders; B J M Vlaminckx Journal: Eur J Clin Microbiol Infect Dis Date: 2014-08-01 Impact factor: 3.267