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Literature DB >> 24092799

Priapism induced by boceprevir-CYP3A4 inhibition and α-adrenergic blockade: case report.

Kyle P Hammond¹, Craig Nielsen, Sunny A Linnebur, Jacob A Langness, Graham Ray, Paul Maroni, Jennifer J Kiser.

Abstract

A 44-year-old white man presented to the emergency department with a 3-day history of priapism requiring a surgically performed distal penile shunt. A drug-drug interaction is the suspected cause whereby CYP3A4 inhibition by boceprevir led to increased exposures of doxazosin, tamsulosin, and/or quetiapine, resulting in additional α-adrenergic blockade.

Entities: Chemical Disease Gene Species

Keywords: boceprevir; drug interaction; priapism; quetiapine; α-adrenergic

Mesh：

Substances：

Year: 2013 PMID： 24092799 PMCID： PMC4049070 DOI： 10.1093/cid/cit673

Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079

20 in total

1. Priapism following ingestion of tamsulosin.

Authors: Peter R Dodds; Stephen J Batter; Scott R Serels
Journal: J Urol Date: 2003-06 Impact factor: 7.450

Review 2. Partial priapism secondary to tamsulosin: a case report and review of the literature.

Authors: M Kilinc; M Piskin; S Guven; R Gurbuz; K Odev; M Kaynar
Journal: Andrologia Date: 2009-06 Impact factor: 2.775

3. Priapism during treatment with olanzapine, quetiapine, and risperidone in a patient with schizophrenia: a case report.

Authors: Kenan M Penaskovic; Fasiha Haq; Shakeel Raza
Journal: Prim Care Companion J Clin Psychiatry Date: 2010

4. In vitro assessment of drug-drug interaction potential of boceprevir associated with drug metabolizing enzymes and transporters.

Authors: Xiaoyan Chu; Xiaoxin Cai; Donghui Cui; Cuyue Tang; Anima Ghosal; Grace Chan; Mitchell D Green; Yuhsin Kuo; Yuexia Liang; Cheri M Maciolek; Jairam Palamanda; Raymond Evers; Thomayant Prueksaritanont
Journal: Drug Metab Dispos Date: 2013-01-04 Impact factor: 3.922

Priapism induced by boceprevir-CYP3A4 inhibition and α-adrenergic blockade: case report.

1. Priapism following ingestion of tamsulosin.

Review 2. Partial priapism secondary to tamsulosin: a case report and review of the literature.

3. Priapism during treatment with olanzapine, quetiapine, and risperidone in a patient with schizophrenia: a case report.

4. In vitro assessment of drug-drug interaction potential of boceprevir associated with drug metabolizing enzymes and transporters.

5. A case of recurrent priapism in the context of quetiapine use, discontinuation, and rechallenge.

Review 6. Review and management of drug interactions with boceprevir and telaprevir.

Review 7. Adrenergic α-blockers: an infrequent and overlooked cause of priapism.

8. Antipsychotic-induced priapism in an HIV patient: a cytochrome P450-mediated drug interaction.

Review 9. Ondansetron metabolism and pharmacokinetics.

10. Testosterone replacement therapy and sleep-related erections in hypogonadal men.

1. Tamsulosin and risk of priapism: A causality assessment using Austin Bradford Hill Criteria.

2. Priapism secondary to tamsulosin: A case report.