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Literature DB >> 240926

The amplitude and the time course of the end-plate current at various pH levels in the frog sartorius muscle.

Abstract

1. The amplitude and the time course of the end-plate current are dependent on the pH of the bathing solution. 2. When pH is changed from 5.4 to 9.4 the amplitude of the end-plate current is increased and its decay is speeded up. 3. The change in the amplitude seems to be a result of a variation of quantal content. 4. The change in the time course of the end-plate current is explained by assuming that the rate constants which determine the dissociation of the receptor-mediator complex are affected by a change in pH. 5. This speculation is supported by the finding that the effect of membrane potential on amplitude and time course of the end-plate current are dependent on pH of the bathing solution.

Entities: Species

Mesh：

Substances：
Acetylcholine

Year: 1975 PMID： 240926 PMCID： PMC1309569 DOI： 10.1113/jphysiol.1975.sp011010

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

21 in total

3. The effect of foreign cations, pH and pharmacological agents on the ionic permeability of an excitatory glutamate synapse.

Authors: R Anwyl
Journal: J Physiol Date: 1977-12 Impact factor: 5.182

4. Current-voltage relation and reversal potential at junctional and extrajunctional ACh-receptors of the frog neuromuscular junction.

Authors: A Mallart; F Dreyer; K Peper
Journal: Pflugers Arch Date: 1976-03-11 Impact factor: 3.657

5. Further investigations on the effect of denervation and pH on the conductance change at the neuromuscular junction of the frog.

Authors: A Trautmann; N F Zilber-Gachelin
Journal: Pflugers Arch Date: 1976-06-29 Impact factor: 3.657

6. Characteristics of fast excitatory postsynaptic current in bullfrog sympathetic ganglion cells. Effects of membrane potential, temperature and Ca ions.

Authors: K Kuba; S Nishi
Journal: Pflugers Arch Date: 1979-01-31 Impact factor: 3.657

The amplitude and the time course of the end-plate current at various pH levels in the frog sartorius muscle.

1. Active phase of frog's end-plate potential.

2. EFFECT OF PH ON THE RESTING MEMBRANE POTENTIAL OF FROG SARTORIUS MUSCLE.

3. On the localization of acetylcholine receptors.

4. Mechanism of the increased acetylcholine sensitivity of skeletal muscle in low pH solutions.

5. The effect of temperature on the neuromuscular junction of the frog.

6. A further study of the statistical composition on the end-plate potential.

7. Affinity, intrinsic activity and drug interactions.

8. The relationship of quaternary ammonium salts to the anionic sites of true and pseudo cholinesterase.

9. An analysis of the end-plate potential recorded with an intracellular electrode.

Review 10. An electrophysiological approach to drug-receptor mechanisms.

1. The effects of pH on the conductance change evoked by iontophoresis in the frog neuromuscular junction.

2. Effect of repetitive stimulation on the frog neuromuscular transmission.

3. The effect of foreign cations, pH and pharmacological agents on the ionic permeability of an excitatory glutamate synapse.

4. Current-voltage relation and reversal potential at junctional and extrajunctional ACh-receptors of the frog neuromuscular junction.

5. Further investigations on the effect of denervation and pH on the conductance change at the neuromuscular junction of the frog.

6. Characteristics of fast excitatory postsynaptic current in bullfrog sympathetic ganglion cells. Effects of membrane potential, temperature and Ca ions.

7. The voltage and temperature dependence of the end-plate current in frog skeletal muscle.

8. Effects of divalent cations on toad end-plate channels.

9. Sites of action of procaine at the motor end-plate.

10. Evidence for acetylcholine receptor blockade by intracellular hydrogen ions in cultured chick myoballs.