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Literature DB >> 24092331

Regulation of the unfolded protein response by microRNAs.

Sylwia Bartoszewska¹, Kinga Kochan², Piotr Madanecki², Arkadiusz Piotrowski², Renata Ochocka², James F Collawn³, Rafal Bartoszewski².

Abstract

The unfolded protein response (UPR) is an adaptive response to the stress that is caused by an accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER). It is an important component of cellular homeostasis. During ER stress, the UPR increases the protein-folding capacity of the endoplasmic reticulum to relieve the stress. Failure to recover leads to apoptosis. Specific cellular mechanisms are required for the cellular recovery phase after UPR activation. Using bioinformatics tools, we identified a number of microRNAs that are predicted to decrease the mRNA expression levels for a number of critical components of the UPR. In this review, we discuss the potential role of microRNAs as key regulators of this pathway and describe how microRNAs may play an essential role in turning off the UPR after the stress has subsided.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
MicroRNAs

Year: 2013 PMID： 24092331 PMCID： PMC3877167 DOI： 10.2478/s11658-013-0106-z

Source DB: PubMed Journal: Cell Mol Biol Lett ISSN： 1425-8153 Impact factor: 5.787

135 in total

1. The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.

Authors: Rafal Bartoszewski; Joseph W Brewer; Andras Rab; David K Crossman; Sylwia Bartoszewska; Niren Kapoor; Cathy Fuller; James F Collawn; Zsuzsa Bebok
Journal: J Biol Chem Date: 2011-10-14 Impact factor: 5.157

2. IRE1 signaling affects cell fate during the unfolded protein response.

Authors: Jonathan H Lin; Han Li; Douglas Yasumura; Hannah R Cohen; Chao Zhang; Barbara Panning; Kevan M Shokat; Matthew M Lavail; Peter Walter
Journal: Science Date: 2007-11-09 Impact factor: 47.728

Review 3. The endoplasmic reticulum and the unfolded protein response.

Authors: Jyoti D Malhotra; Randal J Kaufman
Journal: Semin Cell Dev Biol Date: 2007-09-08 Impact factor: 7.727

4. ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells.

Authors: Daniela M Arduino; A Raquel Esteves; A Filipa Domingues; Claudia M F Pereira; Sandra M Cardoso; Catarina R Oliveira
Journal: BMB Rep Date: 2009-11-30 Impact factor: 4.778

5. The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide.

Authors: Yao Zhao; Huanying Liu; Yuanqi Li; Jianjun Wu; Anne R Greenlee; Chengfeng Yang; Yiguo Jiang
Journal: Toxicol Lett Date: 2011-06-24 Impact factor: 4.372

6. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

Authors: Lori S Hart; John T Cunningham; Tatini Datta; Souvik Dey; Feven Tameire; Stacey L Lehman; Bo Qiu; Haiyan Zhang; George Cerniglia; Meixia Bi; Yan Li; Yan Gao; Huayi Liu; Changhong Li; Amit Maity; Andrei Thomas-Tikhonenko; Alexander E Perl; Albert Koong; Serge Y Fuchs; J Alan Diehl; Ian G Mills; Davide Ruggero; Constantinos Koumenis
Journal: J Clin Invest Date: 2012-11-12 Impact factor: 14.808

7. Mammalian microRNAs predominantly act to decrease target mRNA levels.

Authors: Huili Guo; Nicholas T Ingolia; Jonathan S Weissman; David P Bartel
Journal: Nature Date: 2010-08-12 Impact factor: 49.962

8. ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer.

Authors: Quanlu Duan; Xingxu Wang; Wei Gong; Li Ni; Chen Chen; Xingxing He; Fuqiong Chen; Lei Yang; Peihua Wang; Dao Wen Wang
Journal: PLoS One Date: 2012-02-16 Impact factor: 3.240

9. MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of ΔNP63α and promotes mesenchymal-to-epithelial transition.

Authors: A J DeCastro; K A Dunphy; J Hutchinson; A L Balboni; P Cherukuri; D J Jerry; J DiRenzo
Journal: Cell Death Dis Date: 2013-02-28 Impact factor: 8.469

10. The microRNA.org resource: targets and expression.

Authors: Doron Betel; Manda Wilson; Aaron Gabow; Debora S Marks; Chris Sander
Journal: Nucleic Acids Res Date: 2007-12-23 Impact factor: 16.971

26 in total

Review 1. Ion channels of the lung and their role in disease pathogenesis.

Authors: Rafal Bartoszewski; Sadis Matalon; James F Collawn
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2017-10-12 Impact factor: 5.464

Review 2. MicroRNA in gastrointestinal cell signalling.

Authors: Priyanka Mishra; Divya Singh; Lilly Ganju; Bhuvnesh Kumar
Journal: Inflammopharmacology Date: 2017-11-06 Impact factor: 4.473

3. Response to Persistent ER Stress in Plants: A Multiphasic Process That Transitions Cells from Prosurvival Activities to Cell Death.

Authors: Renu Srivastava; Zhaoxia Li; Giulia Russo; Jie Tang; Ran Bi; Usha Muppirala; Sivanandan Chudalayandi; Andrew Severin; Mingze He; Samuel I Vaitkevicius; Carolyn J Lawrence-Dill; Peng Liu; Ann E Stapleton; Diane C Bassham; Federica Brandizzi; Stephen H Howell
Journal: Plant Cell Date: 2018-05-25 Impact factor: 11.277

4. miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells.

Authors: Rafal Bartoszewski; Marcin Serocki; Anna Janaszak-Jasiecka; Sylwia Bartoszewska; Kinga Kochan-Jamrozy; Arkadiusz Piotrowski; Jarosław Króliczewski; James F Collawn
Journal: Eur J Cell Biol Date: 2017-10-13 Impact factor: 4.492

5. The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells.

Authors: Fabio Arturo Grieco; Andrea Alex Schiavo; Flora Brozzi; Jonas Juan-Mateu; Marco Bugliani; Piero Marchetti; Décio L Eizirik
Journal: J Mol Endocrinol Date: 2019-08 Impact factor: 5.098

6. miR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response.

Authors: Sylwia Bartoszewska; Aleksandra Cabaj; Michał Dąbrowski; James F Collawn; Rafal Bartoszewski
Journal: FASEB J Date: 2019-07-17 Impact factor: 5.191