Literature DB >> 2408914

Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical, biochemical and electrophysiological parameters in the mammalian heart.

R Brückner, S Gramann, M Nose, W Schmitz, H Scholz.   

Abstract

The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) mimicked the effects of isoprenaline on the force of contraction, the cAMP content and the slow Ca++ inward current (Isi) in isolated guinea pig papillary muscles. The results support the hypothesis that phosphodiesterase inhibitors and beta-adrenoceptor agonists exert their positive inotropic effects by increasing Isi via the common mediator cAMP.

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Year:  1985        PMID： 2408914     DOI： 10.1007/bf02012570

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  19 in total

1.  Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium.

Authors:  M Korth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-03       Impact factor: 3.000

Review 2.  Cyclic AMP and contractile activity in heart.

Authors:  R W Tsien
Journal:  Adv Cyclic Nucleotide Res       Date:  1977

3.  Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres.

Authors:  R W Tsien; W Giles; P Greengard
Journal:  Nat New Biol       Date:  1972-12-06

4.  Effects of methylxanthines on adenosine 3',5'-monophosphate and corticosterone in the rat adrenal.

Authors:  A Peytremann; W E Nicholson; G W Liddle; J G Hardman; E W Sutherland
Journal:  Endocrinology       Date:  1973-02       Impact factor: 4.736

5.  Interaction of four methylxanthine compounds and norepinephrine on cardiac phosphorylase activation and cardiac contractility.

Authors:  J H McNeill; M J Brenner; L D Muschek
Journal:  Recent Adv Stud Cardiac Struct Metab       Date:  1973

6.  Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP- and cyclic GMP-dependent effect.

Authors:  M Böhm; R Brückner; I Hackbarth; B Haubitz; R Linhart; W Meyer; B Schmidt; W Schmitz; H Scholz
Journal:  J Pharmacol Exp Ther       Date:  1984-08       Impact factor: 4.030

7.  Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.

Authors:  H Reuter
Journal:  J Physiol       Date:  1974-10       Impact factor: 5.182

Review 8.  Inotropic drugs and their mechanisms of action.

Authors:  H Scholz
Journal:  J Am Coll Cardiol       Date:  1984-08       Impact factor: 24.094

9.  Mode of action of chronotropic agents in cardiac Purkinje fibers. Does epinephrine act by directly modifying the external surface charge?

Authors:  R W Tsien
Journal:  J Gen Physiol       Date:  1974-09       Impact factor: 4.086

10.  Control of action potential duration by calcium ions in cardiac Purkinje fibers.

Authors:  R S Kass; R W Tsien
Journal:  J Gen Physiol       Date:  1976-05       Impact factor: 4.086
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  3 in total

1.  Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.

Authors:  M Böhm; R Brückner; J Neumann; M Nose; W Schmitz; H Scholz
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

2.  Muscarinic receptors mediate negative and positive inotropic effects in mammalian ventricular myocardium: differentiation by agonists.

Authors:  M Korth; V Kühlkamp
Journal:  Br J Pharmacol       Date:  1987-01       Impact factor: 8.739

3.  Electrophysiological characterization of histamine receptor subtypes in mammalian heart preparations.

Authors:  U Borchard; D Hafner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-11       Impact factor: 3.000
  3 in total

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