Literature DB >> 2408703

Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra.

R B Innis, R Andrade, G K Aghajanian.   

Abstract

Substance K (SK) is a newly discovered neuropeptide which is a member of the tachykinin family that includes substance P (SP). As it is present in high concentrations in substantia nigra, we have investigated the electrophysiological activity of SK microiontophoresed onto single neuronal units in this region. SK microiontophoresed onto single units in the substantia nigra caused excitation of approximately 50% of both dopaminergic and non-dopaminergic neurons. This relatively high proportion of responsivity correlates with the reported high density of SK receptors in the substantia nigra.

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Year:  1985        PMID： 2408703     DOI： 10.1016/0006-8993(85)90499-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2, and NK3 tachykinin receptors.

Authors:  L Tremblay; M L Kemel; M Desban; C Gauchy; J Glowinski
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

Review 2.  Organization and physiology of the substantia nigra.

Authors:  H Condé
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

3.  Region specific regulation of glutamic acid decarboxylase mRNA expression by dopamine neurons in rat brain.

Authors:  N Lindefors; S Brene; M Herrera-Marschitz; H Persson
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

4.  Striato-nigral dynorphin and substance P pathways in the rat. II. Functional analysis.

Authors:  M Herrera-Marschitz; I Christensson-Nylander; T Sharp; W Staines; M Reid; T Hökfelt; L Terenius; U Ungerstedt
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

5.  Tissue levels and in vivo release of tachykinins and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation.

Authors:  N Lindefors; E Brodin; U Tossman; J Segovia; U Ungerstedt
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

6.  Neurotensin, substance P, neurokinin-alpha, and enkephalin: injection into ventral tegmental area in the rat produces differential effects on operant responding.

Authors:  A E Kelley; M Cador; L Stinus; M Le Moal
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

7.  Blockade of neurotensin-induced motor activity by inhibition of protein kinase.

Authors:  P W Kalivas
Journal:  Psychopharmacology (Berl)       Date:  1994-02       Impact factor: 4.530

8.  Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.

Authors:  R Bordet; S Ridray; S Carboni; J Diaz; P Sokoloff; J C Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205
  8 in total

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